The aim of this work was produce and characterize solid lipid microparticles (SLMs) with different proportions of fully hydrogenated palm oil (FHPO) and palm oil (PO) as wall material (WM) to encapsulate ascorbic acid (AA), using the spray chilling technique. The microparticles were evaluated for surface morphology (SEM), size distribution and mean diameter, polymorphism, encapsulation efficiency, thermal behavior, DSC, and for release profile. The mean particle diameter ranged from 97.80 to 181.29 μm and the micrographs revealed spherical particles and rough surfaces. The encapsulation efficiency ranged from 80.22 to 93.51% and it was influenced by increases in the concentration of PO in each formulation and by the particle size. All the lipid microparticles presented high thermal resistance and had crystalline behavior β′, proving that after atomization the particles preserved the original polymorphic forms of their constituent materials. Moreover, SLMs gradually released ascorbic acid in aqueous medium, following Higuchi kinetic.

这项工作的目的是使用喷雾冷却法生产和表征具有不同比例的完全氢化棕榈油（FHPO）和棕榈油（PO）作为壁材（WM）的固体脂质微粒（SLM），以封装抗坏血酸（AA）。技术。评价了微粒的表面形态（SEM），尺寸分布和平均直径，多态性，包封效率，热行为，DSC以及释放曲线。平均粒径为97.80至181.29μm，显微照片显示球形颗粒和粗糙表面。包封效率为80.22％至93.51％，并且受每种配方中PO浓度的增加和粒径的影响。所有脂质微粒均表现出高耐热性并具有结晶行为β'，证明在雾化之后，颗粒保留了其构成材料的原始多晶型形式。此外，SLMs遵循Higuchi动力学，逐渐在水性介质中释放抗坏血酸。