The study of two new acylthiourea derivatives (Ar-CO-NH-CS-NH-R) are focused on the bonding interactions supported by X-ray, NMR, UV-Vis, Raman and IR spectroscopy, and NBO, AIM and Hirshfeld surface analysis. The RAHB model is proposed to explain some structural properties. The molecules are stabilized by intra-molecular NH···O bonds arranged in the lattice as centre-symmetric dimers held by inter-molecular NH···S bonds. The dimers are linked to each other through NH···O bonds giving rise to a chain, ribbon-like structure in the network. In vitro bacterial growth inhibition, biofilm formation, biosensor and biofilm metabolic activity were tested considering the broad bioactivity of acylthioureas.

两种新的酰基硫脲衍生物（Ar-CO-NH-CS-NH-R）的研究重点在于X射线，NMR，UV-Vis，拉曼和IR光谱以及NBO，AIM和Hirshfeld表面所支持的键合相互作用分析。提出了RAHB模型来解释一些结构特性。分子通过排列在晶格中的分子内NH···O键稳定为分子间NH···S键所保持的中心对称二聚体。二聚体通过NH···O键相互连接，从而在网络中形成链状，带状结构。考虑到酰基硫脲的广泛生物活性，对体外细菌生长抑制，生物膜形成，生物传感器和生物膜代谢活性进行了测试。