Glass-ceramics for cancer treatment: So close, or yet so far?,Acta Biomaterialia

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Glass-ceramics for cancer treatment: So close, or yet so far?
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2018-11-09 , DOI: 10.1016/j.actbio.2018.11.013
Marta Miola ₁ , Yousef Pakzad ₂ , Sara Banijamali ₃ , Saeid Kargozar ₄ , Chiara Vitale-Brovarone ₁ , Abolfazl Yazdanpanah ₅ , Oana Bretcanu ₆ , Arash Ramedani ₇ , Enrica Vernè ₁ , Masoud Mozafari ₈

Affiliation

Department of Applied Science and Technology, Politecnico di Torino, C.so Duca Degli Abruzzi 24, 10129 Torino, Italy.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 4777-14155, Tehran, Iran.
Engineering Ceramics Research Group, Ceramic Department, Materials and Energy Research Center (MERC), P.O. Box: 4777-14155, Tehran, Iran.
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 917794-8564, Mashhad, Iran.
Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
School of Engineering, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Institute for Nanoscience & Nanotechnology (INST), Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran; Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fedérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 4777-14155, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.

After years of research on the ability of glass-ceramics in bone regeneration, this family of biomaterials has shown revolutionary potentials in a couple of emerging applications such as cancer treatment. Although glass-ceramics have not yet reached their actual potential in cancer therapy, the relevant research activity is significantly growing in this field. It has been projected that this idea and the advent of magnetic bioactive glass-ceramics and mesoporous bioactive glasses could result in major future developments in the field of cancer. Undoubtedly, this strategy needs further developments to better answer the critical questions essential for clinical usage. This review aims to address the existing research developments on glass-ceramics for cancer treatment, starting with the current status and moving to future advances. STATEMENT OF SIGNIFICANCE: Although glass-ceramics have not yet reached their potential in cancer therapy, research activity is significantly growing. It has been speculated that this idea and the advent of modern glass-ceramics could result in significant future advances. Undoubtedly, this strategy needs further investigations and many critical questions have to be answered before it can be successfully applied for cancer treatment. This paper reviews the current state-of-the-art, starting with current products and moving onto recent developments in this field. According to our knowledge, there is a lack of a systematic review on the importance and developments of magnetic bioactive glass-ceramics and mesoporous bioactive glasses for cancer treatment, and it is expected that this review will be of interest to those working in this area.

中文翻译：

用于治疗癌症的玻璃陶瓷：如此接近，或至今？

在对玻璃陶瓷在骨骼再生中的能力进行了多年研究之后，该生物材料家族已在诸如癌症治疗等两个新兴应用中显示出革命性的潜力。尽管玻璃陶瓷在癌症治疗中尚未达到其实际潜力，但是相关的研究活动在该领域中正在显着增长。预计这种想法以及磁性生物活性玻璃陶瓷和中孔生物活性玻璃的出现可能导致癌症领域的未来重大发展。无疑，该策略需要进一步发展，以更好地回答临床使用必不可少的关键问题。这篇综述旨在解决玻璃陶瓷用于癌症治疗的现有研究进展，从目前的状态开始，然后发展到未来的进展。重要性声明：尽管玻璃陶瓷尚未达到其在癌症治疗中的潜力，但研究活动正在显着增长。据推测，这种想法和现代玻璃陶瓷的出现可能会导致未来的重大进步。无疑，该策略需要进一步研究，许多关键问题必须先得到回答，然后才能成功应用于癌症治疗。本文回顾了当前的最新技术，从当前的产品开始，然后介绍该领域的最新发展。根据我们的知识，对于磁性生物活性玻璃陶瓷和中孔生物活性玻璃在癌症治疗中的重要性和发展尚缺乏系统的综述，并且希望该综述对从事该领域的人员感兴趣。尽管玻璃陶瓷尚未在癌症治疗中发挥其潜力，但研究活动正在显着增长。据推测，这种想法和现代玻璃陶瓷的出现可能会导致未来的重大进步。无疑，该策略需要进一步研究，许多关键问题必须先得到回答，然后才能成功应用于癌症治疗。本文回顾了当前的最新技术，从当前的产品开始，然后介绍该领域的最新发展。根据我们的知识，对于磁性生物活性玻璃陶瓷和中孔生物活性玻璃在癌症治疗中的重要性和发展尚缺乏系统的综述，并且希望该综述对从事该领域的人员感兴趣。尽管玻璃陶瓷尚未在癌症治疗中发挥其潜力，但研究活动正在显着增长。据推测，这种想法和现代玻璃陶瓷的出现可能会导致未来的重大进步。无疑，该策略需要进一步研究，许多关键问题必须先得到回答，然后才能成功应用于癌症治疗。本文回顾了当前的最新技术，从当前的产品开始，然后介绍该领域的最新发展。根据我们的知识，对于磁性生物活性玻璃陶瓷和中孔生物活性玻璃在癌症治疗中的重要性和发展尚缺乏系统的综述，并且希望该综述对从事该领域的人员感兴趣。

更新日期：2018-11-09

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