The Molecular Dance of Fibronectin: Conformational Flexibility Leads to Functional Versatility.,Biomacromolecules

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The Molecular Dance of Fibronectin: Conformational Flexibility Leads to Functional Versatility.
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-11-27 , DOI: 10.1021/acs.biomac.8b01258
Raffaele Mezzenga ₁ , Maria Mitsi ₁

Affiliation

Fibronectin, a large multimodular protein and one of the major fibrillar components of the extracellular matrix, has been the subject of study for many decades and plays critical roles in embryonic development and tissue homeostasis. Moreover, fibronectin has been implicated in the pathology of many diseases, including cancer, and abnormal depositions of fibronectin have been identified in a number of amyloid and nonamyloid lesions. The ability of fibronectin to carry all these diverse functionalities depends on interactions with a large number of molecules, including adhesive and signaling cell surface receptors, other components of the extracellular matrix, and growth factors and cytokines. The regulation and integration of such large number of interactions depends on the modular architecture of fibronectin, which allows a large number of conformations, exposing or destroying different binding sites. In this Review, we summarize the current knowledge regarding the conformational flexibility of fibronectin, with an emphasis on how it regulates the ability of fibronectin to interact with various signaling molecules and cell-surface receptors and to form supramolecular assemblies and fibrillar structures.

中文翻译：

纤连蛋白的分子舞蹈：构象灵活性导致功能的多功能性。

纤连蛋白是一种大的多模块蛋白，是细胞外基质的主要原纤维成分之一，数十年来一直是研究的主题，并在胚胎发育和组织稳态中起着至关重要的作用。此外，纤连蛋白已经牵涉到许多疾病的病理学中，包括癌症，并且已经在许多淀粉样和非淀粉样蛋白损伤中鉴定出纤连蛋白的异常沉积。纤连蛋白具有所有这些不同功能的能力取决于与大量分子的相互作用，包括粘附和信号传导的细胞表面受体，细胞外基质的其他成分以及生长因子和细胞因子。如此大量相互作用的调控和整合取决于纤连蛋白的模块化架构，它允许大量构象，暴露或破坏不同的结合位点。在这篇综述中，我们总结了有关纤连蛋白构象柔性的当前知识，重点在于它如何调节纤连蛋白与各种信号分子和细胞表面受体相互作用并形成超分子组装和纤丝结构的能力。

更新日期：2018-11-07

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