Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs). We subsequently discovered that one of these oncRNAs, which originates from the 3' end of TERC, acts as a regulator of gene expression and is a robust promoter of breast cancer metastasis. This oncRNA, which we have named T3p, exerts its prometastatic effects by acting as an inhibitor of RISC complex activity and increasing the expression of the prometastatic genes NUPR1 and PANX2. Furthermore, we have shown that oncRNAs are present in cancer-cell-derived extracellular vesicles, raising the possibility that these circulating oncRNAs may also have a role in non-cell autonomous disease pathogenesis. Additionally, these circulating oncRNAs present a novel avenue for cancer fingerprinting using liquid biopsies.

中文翻译：

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癌细胞利用孤儿RNA驱动转移进程。

在这里，我们进行了系统的搜索，以鉴定乳腺癌特异性的小非编码RNA，我们将其统称为孤儿非编码RNA（oncRNA）。我们随后发现，这些oncRNA之一起源于TERC的3'端，可作为基因表达的调节剂，并且是乳腺癌转移的强大启动子。我们将其命名为T3p，该oncRNA通过充当RISC复合物活性的抑制剂并增加前转移基因NUPR1和PANX2的表达来发挥其前转移作用。此外，我们已经表明，癌细胞来源的细胞外囊泡中存在oncRNAs，从而增加了这些循环中的oncRNAs也可能在非细胞自主性疾病发病机理中发挥作用的可能性。此外，