Injured human skin fails to regenerate, resulting in scar formation. Annually, 100 million new skin-scarring incidents, occurring as a result of surgery, disease, burns, or sports-related damage, remain untreated. Here, we review knowledge gained from scar-free experimental animal models that have natural regenerative mechanisms for scar-free skin recovery. We also focus on the unique role of endogenous stem cells and other cellular and molecular factors, including the balance of the transforming growth factor-beta (TGF-β) pathway in the context of human skin regeneration. This new strategy opens a new window in drug development for scar-free skin regeneration treatments in both the clinical and cosmetic practice settings.

受伤的人类皮肤无法再生，导致疤痕形成。每年，由于外科手术，疾病，烧伤或与运动相关的损害而导致的1亿起新的皮肤瘢痕事件仍未得到治疗。在这里，我们回顾了从无疤痕实验动物模型获得的知识，这些动物模型具有无疤痕皮肤恢复的自然再生机制。我们还关注内源性干细胞以及其他细胞和分子因素的独特作用，包括在人类皮肤再生过程中转化生长因子-β（TGF-β）途径的平衡。这种新策略为临床和美容实践环境中的无疤痕皮肤再生治疗药物开发开辟了新窗口。