Bacteria Hunt Bacteria through an Intriguing Cyclic Peptide,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bacteria Hunt Bacteria through an Intriguing Cyclic Peptide
ChemMedChem ( IF 3.6 ) Pub Date : 2018-12-10 , DOI: 10.1002/cmdc.201800597
Shimaa A. H. Abdel Monaim _{1,

2} , Anou M. Somboro ₃ , Ayman El-Faham _{4,

5} , Beatriz G. de la Torre ₁ , Fernando Albericio _{2,

4,

6}

Affiliation

In the last few decades, peptides have been victorious over small molecules as therapeutics due to their broad range of applications, high biological activity, and high specificity. However, the main challenges to overcome if peptides are to become effective drugs is their low oral bioavailability and instability under physiological conditions. Cyclic peptides play a vital role in this context because they show higher stability under physiological conditions, higher membrane permeability, and greater oral bioavailability than that of their corresponding linear analogues. In this regard, cyclic antimicrobial peptides (AMPs) have gained considerable attention in the field of novel antibiotic development. Bacterial strains produce cyclic AMPs through two pathways: ribosomal and nonribosomal. This review provides an overview of the chemical classification of cyclic AMPs isolated from bacteria, and provides a description of their biological activity and mode of action.

中文翻译：

细菌通过一个有趣的环肽寻找细菌

在过去的几十年中，肽因其广泛的应用范围，高的生物活性和高的特异性而在小分子治疗领域取得了胜利。然而，如果肽要成为有效的药物，要克服的主要挑战是其低的口服生物利用度和在生理条件下的不稳定性。环状肽在这种情况下起着至关重要的作用，因为与相应的线性类似物相比，环状肽在生理条件下显示出更高的稳定性，更高的膜通透性和更高的口服生物利用度。在这方面，在新型抗生素开发领域中，环状抗微生物肽（AMP）已引起相当大的关注。细菌菌株通过两种途径产生环状AMP：核糖体和非核糖体。

更新日期：2018-12-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11