Calcium phosphate cements (CPCs) are frequently used as synthetic bone substitute, but their intrinsic low fracture toughness impedes their application in highly loaded skeletal sites. However, fibers can be used to reduce the brittleness of these CPCs provided that the affinity between the fibers and cement matrix facilitates the transfer of loads from the matrix to the fibers. The aim of the present work was to improve the interface between hydrophobic polylactic acid (PLA) microfibers and hydrophilic CPC. To this end, calcium-binding alendronate groups were conjugated onto the surface of PLA microfibers via different strategies to immobilize a tunable amount of alendronate onto the fiber surface. CPCs reinforced with PLA fibers revealed toughness values which were up to 50-fold higher than unreinforced CPCs. Nevertheless, surface functionalization of PLA microfibers with alendronate groups did not improve the mechanical properties of fiber-reinforced CPCs.

磷酸钙水泥（CPC）经常用作合成骨的替代品，但其固有的低断裂韧性阻碍了其在高负荷骨骼部位的应用。但是，如果纤维与水泥基体之间的亲和力有利于将载荷从基体转移到纤维上，则可以使用纤维来降低这些CPC的脆性。本工作的目的是改善疏水性聚乳酸（PLA）超细纤维和亲水性CPC之间的界面。为此，通过不同策略将结合钙的阿仑膦酸酯基团缀合到PLA微纤维的表面上，以将可调节量的阿仑膦酸酯固定在纤维表面上。用PLA纤维增强的CPC的韧性值比未增强的CPC高50倍。尽管如此，