Twelve previously undescribed lanostane-type triterpenoids, including three triterpenoids with a γ-lactone ring, namely applanlactones A‒C, four highly oxygenated lanostane triterpenoids, namely methyl applaniate A and applanoic acids B‒D, as well as five C21 nortriterpenoids, applanones A‒E were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat.. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as X-ray crystallographic analyses. Meanwhile, applanlactone A, methyl applaniate A and applanoic acid B showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-β1 (TGF-β1) in vitro.

中文翻译：

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来自灵芝子实体的羊毛甾烷型三萜类化合物

十二种以前未描述的羊毛脂类三萜类化合物，包括三种具有 γ-内酯环的三萜类化合物，即 applanlactones A-C、四种高氧羊毛脂烷三萜类化合物，即甲基 applanate A 和 applanoic酸 B-D，以及五种 C21 去甲三萜类化合物，applanones A ‒E 是从 Ganoderma applanatum (Pers.) Pat. 的子实体中分离出来的。通过一维、二维 NMR 和 MS 光谱以及 X 射线晶体学分析阐明了它们的结构。同时，applanlactone A、甲基applanate A和applanoic acid B在体外对转化生长因子-β1（TGF-β1）诱导的肝星状细胞（HSC）的增殖具有抑制作用。