A novel electrochemical sensor based on a graphene oxide (GO)/three-dimensional (3D) hierarchical zinc oxide (ZnO) nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol (CAP). The hierarchical ZnO structure consisting of nanosheets was synthesized by a green aqueous solution procedure and then composited with GO through a simple sonochemical method. The synthesized ZnO and GO/ZnO nanomaterials were characterized by scanning electron microscopy (SEM), elemental mapping, X-ray diffraction (XRD), UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The electrochemical performance of the prepared GO/ZnO/glassy carbon electrode (GCE) was evaluated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The GO/ZnO/GCE shows a low CAP detection limit of 0.01 μM, a high sensitivity of 7.27 μA μM⁻¹ cm⁻², and a linear response in the range of 0.2 to 7.2 μM. Moreover, it exhibits excellent stability, reproducibility and repeatability. Practicality of the sensor has further been demonstrated with honey, milk and eye drop samples.

中文翻译：

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基于氧化石墨烯/多级氧化锌纳米复合材料的抗生素药物氯霉素的电化学检测

为了有效测定抗生素氯霉素（CAP），开发了一种基于氧化石墨烯（GO）/三维（3D）分级氧化锌（ZnO）纳米复合材料的新型电化学传感器。通过绿色水溶液程序合成了由纳米片组成的分层ZnO结构，然后通过简单的声化学方法将其与GO进行了复合。通过扫描电子显微镜（SEM），元素图谱，X射线衍射（XRD），紫外可见光谱，傅立叶变换红外光谱（FT-IR）和拉曼光谱对合成的ZnO和GO / ZnO纳米材料进行了表征。使用循环伏安法（CV）和微分脉冲伏安法（DPV）技术评估了制备的GO / ZnO /玻碳电极（GCE）的电化学性能。^-1 cm ^-2，并且线性响应在0.2至7.2μM的范围内。此外，它具有极好的稳定性，可重复性和可重复性。蜂蜜，牛奶和眼药水样本进一步证明了该传感器的实用性。