Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization,Macromolecular Rapid Communications

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Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-11-02 , DOI: 10.1002/marc.201800678
Gijs Ramakers ₁ , Claudio D'Incal ₁ , Mick Gagliardi ₂ , Daniël G. M. Molin ₂ , Tanja Junkers _{1,

3}

Affiliation

Functional synthetic polymers are frequently explored for their use in the biomedical field. To fulfill the stringent demands of biodegradability and compatibility, the materials need to be versatile and tunable. Post‐modification is often considered challenging for well‐known degradable materials like poly(lactic acid) because of their chemical inertness. In this work a procedure is proposed to produce densely functionalized polymer particles using oligomeric precursors synthesized via the Morita–Baylis–Hillman reaction. This allows for a variety of post‐modification reactions to serve bio‐conjugation or tuning of the material properties. The particles are subjected to basic media and found to be degradable. Furthermore, cytotoxicity tests confirm good biocompatibility. Finally, as a proof of concept to demonstrate the versatility of the particles, post‐modification reactions are carried out through the formation of imines.

中文翻译：

由Morita–Baylis–Hillman聚合合成功能性聚合物粒子

官能合成聚合物在生物医学领域中的用途经常被探索。为了满足对生物可降解性和相容性的严格要求，材料必须具有通用性和可调性。对于改性聚乳酸等众所周知的可降解材料，由于其化学惰性，通常认为后改性具有挑战性。在这项工作中，提出了一种使用通过Morita-Baylis-Hillman反应合成的低聚物前体生产致密官能化聚合物颗粒的程序。这允许进行多种修饰后反应，以实现生物共轭或调节材料性能。颗粒经受碱性介质的作用，发现是可降解的。此外，细胞毒性测试证实了良好的生物相容性。最后，

更新日期：2018-11-02

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