This article focuses on providing a systematic review on various fundamental properties of composite based on poly(α-hydroxy esters) and hydroxyapatite (HAp) for application in bone tissue engineering. Poly(α-hydroxy esters), a well-known synthetic biopolymer has attracted considerable interest to be employed for synthesis of bone graft substitute material with HAp mainly due to its bioresorbability, variable biodegradation rate and melt-processibility. Such features are simultaneously attractive for both biomedical application and industrial-scale productions. Besides the main function of hydroxyapatite as bioactive ceramic filler in composite to induce new bone formation upon polymer bioresorption, HAp can also serve as reinforcement for matrix polymer by providing sufficient mechanical support for cell attachment. Moreover, HAp plays a significant role in determining other composite properties, such as resistance to ingress of body fluid, body temperature ageing, relaxation movement of polymer segment, and in vivo biodegradation. These properties constitute as the fundamental requirements in field of bone tissue regeneration which is desirable to be achieved by unique composite system based on poly(α-hydroxyesters) and HAp particles.

中文翻译：

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用于聚（α-羟基酯）生物复合材料的羟基磷灰石

本文着重于对基于聚（α-羟基酯）和羟基磷灰石（HAp）的复合材料的各种基本性能进行系统的综述，以用于骨组织工程。聚（α-羟基酯），一种众所周知的合成生物聚合物，由于其生物吸收性，可变的生物降解速率和熔体加工性而引起了广泛的兴趣，可用于合成具有HAp的骨移植替代材料。这些特征同时对于生物医学应用和工业规模生产都具有吸引力。除了羟基磷灰石作为复合物中生物活性陶瓷填料的主要功能以在聚合物生物吸收后诱导新的骨形成外，HAp还可以通过为细胞附着提供足够的机械支持来充当基质聚合物的增强剂。而且，体内生物降解。这些性质构成了骨组织再生领域中的基本要求，这是通过基于聚（α-羟基酯）和HAp颗粒的独特复合系统来实现的。