Upgrading Cross-Coupling Reactions for Biaryl Syntheses,Accounts of Chemical Research

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Upgrading Cross-Coupling Reactions for Biaryl Syntheses
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-10-30 00:00:00 , DOI: 10.1021/acs.accounts.8b00408
Yun-Fei Zhang _{1,

2} , Zhang-Jie Shi _{1,

3,

4}

Affiliation

Transition-metal catalyzed cross-coupling reactions have emerged as a powerful tool for constructing biaryl compounds. Aryl halides and aryl metallic reagents (typically prepared from aryl halides) are used as coupling partners. It would be desirable to replace either aryl halide or aryl metallic reagents used in cross-couplings reactions with more readily available surrogates. Oxidative dehydrogenative cross-coupling between two different “inert” aryl C–H bonds represents an ideal system that would revolutionize cross-coupling chemistry. Furthermore, cross-coupling reactions might be improved by developing new catalytic protocols based on cheap transition-metal catalysts or even transition-metal-free systems to decrease costs and avoid the use of heavy metal and noble transition metals. It would be desirable to promote both catalytic systems and replace either or both coupling partners.

中文翻译：

升级联芳基合成的交叉偶联反应

过渡金属催化的交叉偶联反应已成为构建联芳基化合物的有力工具。芳基卤化物和芳基金属试剂（通常由芳基卤化物制备）用作偶联伙伴。希望用更容易获得的替代物代替交叉偶联反应中使用的芳基卤化物或芳基金属试剂。两个不同的“惰性”芳基C–H键之间的氧化脱氢交叉偶联代表了彻底改变交叉偶联化学反应的理想系统。此外，可以通过开发基于廉价过渡金属催化剂或什至不含过渡金属的系统的新催化方案来改善交叉偶联反应，以降低成本并避免使用重金属和贵金属。

更新日期：2018-10-30

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