Objective

Experiencing depression in adolescence can disrupt important developmental processes, which can have longstanding effects on socioeconomic status and relationships. The objective of this article was to systematically review the evidence examining associations between adolescent depression and adult psychosocial outcomes.

Method

Five databases (MEDLINE, Embase, PsycINFO, CINAHL, and ERIC) were searched for articles published from 1980 through March 2017. Eligible articles were peer reviewed, published in English, had prospective cohort study designs, and contrasted adult psychosocial outcomes in those with versus without adolescent depression. Outcomes with sufficient data were pooled using random-effects meta-analyses, with summary measures reported as odds ratios (ORs). A protocol for this review was registered on PROSPERO (CRD42017059662).

Results

Of the 4,988 references screened for inclusion, 31 articles comprising 136 analyses were included for review. Twenty-four cohorts were represented. Seventy-seven analyses across 10 outcomes were meta-analyzed, with remaining analyses summarized narratively. Meta-analyses suggested that adolescent depression was associated with outcomes including, but not limited to, failure to complete secondary school (OR 1.76, 95% CI 1.29–2.39), unemployment (OR 1.66, 95% CI 1.29–2.14), and pregnancy/parenthood (OR 1.38, 95% CI 1.06–1.81).

Conclusion

This review demonstrates that adolescent depression is associated with a myriad of adult psychosocial outcomes. Many are linked and can lead to the propagation of difficulties across the lifespan. These findings can have important implications for encouraging the provision of targeted mental health care early in development to improve life chances.

中文翻译：

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系统评价和荟萃分析：青少年抑郁症和长期社会心理结果

客观的

青春期抑郁会破坏重要的发育过程，这可能对社会经济地位和人际关系产生长期影响。本文的目的是系统地审查检查青春期抑郁与成人心理社会后果之间关系的证据。

方法

搜索五个数据库（MEDLINE，Embase，PsycINFO，CINAHL和ERIC）以查找1980年至2017年3月之间发表的文章。对符合条件的文章进行同行评审，以英语发表，具有前瞻性队列研究设计，并对比那些与没有青春期抑郁症。使用随机效应荟萃分析汇总具有足够数据的结果，并以比值比（OR）报告汇总指标。此审查的协议已在PROSPERO（CRD42017059662）上进行了注册。

结果

在筛选出的4,988篇参考文献中，包括136种分析的31篇文章被纳入审查。代表了二十四个队列。对10项结果的77项分析进行了荟萃分析，其余的分析均以叙述方式进行了总结。荟萃分析表明，青少年抑郁与结局有关，包括但不限于中学毕业失败（OR 1.76，95％CI 1.29–2.39），失业（OR 1.66，95％CI 1.29–2.14）和怀孕。 /父母身分（OR 1.38，95％CI 1.06-1.81）。

结论

这项审查表明，青春期抑郁症与成年的许多社会心理结果有关。许多问题是相互联系的，并且可能导致困难在整个生命周期中传播。这些发现可能对鼓励在发展初期提供有针对性的精神卫生保健以改善生活机会具有重要意义。