BACKGROUND It is general opinion that histopathology is nonspecific and of little value in diagnosing erosive pustular dermatosis of the scalp (EPDS). OBJECTIVES Clinicopathologic correlation of erosive pustular dermatosis of the scalp. METHODS We reviewed the clinical and pathologic records of patients with a clinicopathologic diagnosis of EPDS between 2011 and 2016 at the Dermatopathology Unit of Turin University. RESULTS Thirty elderly patients with EPDS were identified (22 men and 8 women). Androgenetic alopecia was present in 19 of 30 patients. Triggering factors included mechanical trauma in 10 of 30 cases, surgical procedures in 4 of 30 cases, and herpes zoster in 1 of 30 cases. Three patients were affected by autoimmune disorders. The vertex was the most common location. Disease presentation varied markedly from tiny, erosive, scaly lesions to crusted and hemorrhagic plaques, mimicking pustular pyoderma gangrenosum. The pathologic changes differed according to lesion type and disease duration. Interestingly, a spongiotic and suppurative infundibulo-folliculitis was observed in 8 of 30 cases. LIMITATIONS This was a retrospective study. CONCLUSIONS We believe that the primary lesion of erosive pustular dermatosis of the scalp is a spongiotic, pustular superficial folliculitis. The clinicopathologic similarities with other neutrophilic dermatoses, such as pustular pyoderma gangrenosum, suggest this condition should be included in this spectrum, where pathergy plays a pathogenetic role.

中文翻译：

---

头皮糜烂性脓疱性皮肤病：中性粒细胞性皮肤病范围内的中性粒细胞性毛囊炎：30例临床病理研究。

背景技术一般认为，组织病理学是非特异性的，并且在诊断头皮糜烂性脓疱性皮肤病（EPDS）中没有什么价值。目的头皮糜烂性脓疱性皮肤病的临床病理相关性。方法我们回顾了都灵大学皮肤病理科2011年至2016年间患有EPDS临床病理诊断的患者的临床和病理记录。结果确定了30例老年EPDS患者（22例男性和8例女性）。30名患者中有19名存在雄激素性脱发。触发因素包括机械损伤30例中的10例，外科手术30例中的4例，带状疱疹30例中的1例。三名患者患有自身免疫性疾病。顶点是最常见的位置。疾病表现形式从微小，侵蚀性，鳞状病变至结to和出血性斑块，模仿脓疱性坏疽性脓皮病。病理变化根据病变类型和疾病持续时间而有所不同。有趣的是，在30例中的8例中观察到了海绵状和化脓性漏斗性毛囊炎。局限性这是一项回顾性研究。结论我们认为头皮糜烂性脓疱性皮肤病的主要病变是海绵状脓疱性浅表性毛囊炎。与其他中性粒细胞性皮肤病（如脓疱性坏疽性脓性脓皮性脓皮病）的临床病理相似性表明，这种情况应包括在此范围内，其中病理反应起着致病作用。在30例中的8例中观察到了海绵状和化脓性漏斗性毛囊炎。局限性这是一项回顾性研究。结论我们认为头皮糜烂性脓疱性皮肤病的主要病变是海绵状脓疱性浅表性毛囊炎。与其他中性粒细胞性皮肤病（如脓疱性坏疽性脓性脓皮性脓皮病）的临床病理相似性表明，这种情况应包括在此范围内，其中病理反应起着致病作用。在30例中的8例中观察到了海绵状和化脓性漏斗性毛囊炎。局限性这是一项回顾性研究。结论我们认为头皮糜烂性脓疱性皮肤病的主要病变是海绵状脓疱性浅表性毛囊炎。与其他中性粒细胞性皮肤病（如脓疱性坏疽性脓性脓皮性脓皮病）的临床病理相似性表明，这种情况应包括在此范围内，其中病理反应起着致病作用。