Mitochondrial homeostasis is important for the health and well-being of organ systems and organisms. Mitochondrial dysfunction is known to be the cause and consequence of metabolic diseases, including obesity, diabetes, cancer, neurodegeneration, cerebrovascular, and cardiovascular disease. For cardiovascular tissue, which relies mostly on oxidative phosphorylation, the role of mitochondria is inevitable. Rather than being biomarkers of mitochondrial health, miRNAs are now known as bioregulators of this important feature. Recent studies have shown a close interaction between Forkhead box other 1 (FoxO1) transcription factors and miRNAs in the cardiovascular system. These interactions have also been shown to regulate mitochondrial homeostasis. In this review, I highlight how understanding FoxO1 and miRNA interacting networks could enable us to limit mitochondrial dysfunction and associated pathologies.

线粒体稳态对于器官系统和生物的健康与福祉非常重要。线粒体功能障碍是代谢性疾病的起因和后果，包括肥胖症，糖尿病，癌症，神经退行性疾病，脑血管疾病和心血管疾病。对于主要依赖于氧化磷酸化的心血管组织，线粒体的作用是不可避免的。现在，miRNA不再是线粒体健康的生物标志物，而是被称为具有此重要特征的生物调节剂。最近的研究表明，叉头盒其他1（FoxO1）转录因子与心血管系统中的miRNA之间存在密切的相互作用。这些相互作用还显示出调节线粒体稳态。在这篇评论中，