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Imbalance of the two main circulating dendritic cell subsets in patients with myasthenia gravis.
Clinical Immunology ( IF 4.5 ) Pub Date : 2018-10-22 , DOI: 10.1016/j.clim.2018.10.012
Pei Chen 1 , Yingkai Li 1 , Hao Huang 2 , Yan Li 3 , Xin Huang 1 , Zhenguang Chen 4 , Xiaoxi Liu 1 , Li Qiu 1 , Changyi Ou 1 , Zhidong Huang 1 , Zhongqiang Lin 1 , Hao Ran 5 , Weibin Liu 1
Affiliation  

Although it is well documented that circulating dendritic cells (DCs) have specialized features during many kinds of physiological and pathological conditions, there are few reports about the features of DCs in the peripheral blood of myasthenia gravis (MG) patients. We investigated the quantitative and component features of DCs and their implications in MG. Peripheral blood samples from different kinds of MG patients were collected and their clinical characteristics were recorded. Using flow cytometry, we distinguished circulating DC subsets [plasmacytoid DCs (pDCs) and myeloid DCs (mDCs)] and enumerated their densities in peripheral blood. Absolute numbers of circulating pDCs were significantly decreased in naïve MG patients compared with healthy controls, resulting in a markedly lower ratio of the pDC to mDC percentage in total circulating DCs (pDCs/mDCs), suggesting an imbalance in the proportions of the two main circulating DC subsets. The clinical status of MG patients was improved after drug treatment, together with increased pDCs/mDCs. In a longitudinal follow-up, we observed that circulating mDCs were significantly reduced after 1 month of therapy with a corticosteroid and immunosuppressant, resulting in recovery of pDCs/mDCs. Although the exact meaning of the proportion change in circulating DC subsets is unknown, pDCs/mDCs might reflect the balance between the autoimmune response and immune tolerance of a patient. Moreover, changes in pDCs/mDCs during treatment might be a promising marker to predict the efficacy of a specific drug used for MG patients.

中文翻译:

重症肌无力患者的两个主要循环树突状细胞亚群失衡。

尽管有充分的文献证明循环树突状细胞(DC)在多种生理和病理状况下具有特定的特征,但关于重症肌无力(MG)患者外周血中DC的特征的报道很少。我们研究了DC的定量和组成特征及其在MG中的含义。收集不同类型的MG患者的外周血样本,并记录其临床特征。使用流式细胞仪,我们区分了循环DC子集[浆细胞样DC(pDC)和髓样DC(mDC)],并列举了它们在外周血中的密度。与健康对照组相比,未患过MG的患者中循环pDC的绝对数量显着降低,导致总循环DC(pDC / mDC)中pDC与mDC百分比的比率明显降低,这表明两个主要循环DC子集的比例不平衡。药物治疗后,MG患者的临床状况得到改善,同时pDCs / mDCs增加。在纵向随访中,我们观察到皮质类固醇和免疫抑制剂治疗1个月后循环mDCs显着减少,导致pDCs / mDCs恢复。尽管循环DC亚组中比例变化的确切含义尚不清楚,但pDC / mDC可能反映了患者自身免疫反应与免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。这表明两个主要循环DC子集的比例不平衡。药物治疗后,MG患者的临床状况得到改善,同时pDCs / mDCs增加。在纵向随访中,我们观察到皮质类固醇和免疫抑制剂治疗1个月后循环mDCs显着减少,导致pDCs / mDCs恢复。尽管尚不清楚循环DC亚群中比例变化的确切含义,但pDC / mDC可能反映了患者自身免疫反应和免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。这表明两个主要循环DC子集的比例不平衡。药物治疗后,MG患者的临床状况得到改善,同时pDCs / mDCs增加。在纵向随访中,我们观察到皮质类固醇和免疫抑制剂治疗1个月后循环mDCs显着减少,导致pDCs / mDCs恢复。尽管循环DC亚组中比例变化的确切含义尚不清楚,但pDC / mDC可能反映了患者自身免疫反应与免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。以及增加的pDC / mDC。在纵向随访中,我们观察到皮质类固醇和免疫抑制剂治疗1个月后循环mDCs显着减少,导致pDCs / mDCs恢复。尽管循环DC亚组中比例变化的确切含义尚不清楚,但pDC / mDC可能反映了患者自身免疫反应与免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。以及增加的pDC / mDC。在纵向随访中,我们观察到皮质类固醇和免疫抑制剂治疗1个月后循环mDCs显着减少,导致pDCs / mDCs恢复。尽管尚不清楚循环DC亚群中比例变化的确切含义,但pDC / mDC可能反映了患者自身免疫反应和免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。尽管循环DC亚组中比例变化的确切含义尚不清楚,但pDC / mDC可能反映了患者自身免疫反应与免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。尽管循环DC亚组中比例变化的确切含义尚不清楚,但pDC / mDC可能反映了患者自身免疫反应与免疫耐受之间的平衡。此外,治疗期间pDC / mDC的变化可能是预测MG患者所用特定药物疗效的有前途的标志。
更新日期:2018-10-22
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