Quantum dots with unique optical and chemical properties show great potential applications in biology and chemical and medical science. Nevertheless, their practical applications in various fields are greatly limited due to the presence of hydrophobic organic surfaces. In this paper, we report a simple and effective method based on ligand exchange and proton donor-receptor reaction to prepare ultrastable and amphiphilic quantum dots having bilayer ligands with ultidentate structure, which provide active sites for subsequent functional conjugation. Our results show that these quantum dots exhibit monodispersity, excellent stability and solvent-free fluidity. In addition, they maintain their optical properties in a chemical environment due to the large amount of amphiphilic amine salts as ligands, which also endow quantum dots with lower cytotoxicity and higher antibacterial activity. The synthesis strategy in this study provides a new insight into the design and fabrication of promising multifunctional materials for biology, medicine, and energy and display technologies.

中文翻译：

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具有多齿双层配体和流变行为的超稳定量子点的包封和增溶†

具有独特的光学和化学性质的量子点在生物学，化学和医学科学中显示出巨大的潜在应用。然而，由于存在疏水性有机表面，它们在各个领域的实际应用受到很大限制。在本文中，我们报告了一种基于配体交换和质子供体-受体反应的简单有效的方法，以制备具有双层结构配体的超稳定且两亲的量子点，这些分子为后续的功能共轭提供了活性位点。我们的结果表明，这些量子点表现出单分散性，出色的稳定性和无溶剂流动性。另外，由于大量的两亲胺盐作为配体，它们在化学环境中仍保持其光学性质，这也赋予量子点较低的细胞毒性和较高的抗菌活性。这项研究中的合成策略为生物学，医学，能源和展示技术的有前景的多功能材料的设计和制造提供了新的见识。