Background

Inositol polyphosphate 5-phosphatase (INPP5A) has been shown to play a role in development and progression of cutaneous squamous cell carcinoma (cSCC). The goal of the current study was to explore the prognostic value of INPP5A expression in cSCC.

Methods

A total of 189 cases of actinic keratosis and SCC in 174 patients were identified; clinical and outcome data were abstracted, histopathology was rereviewed, and immunohistochemical staining and interpretation was performed for INPP5A.

Results

The majority of tumors (89.4%) had an INPP5A score of 2 or 3. No patients had complete loss of INPP5A. Tumors with an INPP5A score of 1 were more likely to be intermediate- to high-risk tumors (Brigham and Women's Hospital stage ≥T2a 85.0% vs 23.7% [P < .0001]) characterized by a larger diameter (2.4 cm vs 1.3 cm [P = .0004]), moderate-to-poor differentiation (86.7% vs 17.6% [P < .0001]), and perineural invasion (37.5% vs 5.3%, [P < .0001]). An INPP5A score of 1 was associated with a worse 3-year survival (a rate of 42.3% [hazard ratio, 2.81, P = .0006]) and a local metastasis rate of 48.0% (hazard ratio, 4.71; P < .0001).

Conclusions

Low INPP5A scores are predictive of aggressive tumors and may be a useful adjunct to guide clinical management of cSCC.

中文翻译：

---

肌醇多磷酸5-磷酸酶对皮肤鳞状细胞癌的预后价值

背景

肌醇多磷酸 5-磷酸酶 (INPP5A) 已被证明在皮肤鳞状细胞癌 (cSCC) 的发生和进展中发挥作用。本研究的目的是探讨 INPP5A 表达在 cSCC 中的预后价值。

方法

174 名患者中，共鉴定出 189 例光化性角化病和鳞状细胞癌；提取临床和结果数据，重新审查组织病理学，并对 INPP5A 进行免疫组织化学染色和解释。

结果

大多数肿瘤 (89.4%) 的 INPP5A 评分为 2 或 3。没有患者的 INPP5A 完全丧失。INPP5A 评分为 1 的肿瘤更有可能是中高危肿瘤（布莱根妇女医院分期 ≥T2a 85.0% vs 23.7% [ P < .0001]），其特点是直径较大（2.4 cm vs 1.3 cm  ） [ P  = .0004]）、中度至低分化（86.7% vs 17.6% [ P  < .0001]）和神经周围侵犯（37.5% vs 5.3%，[ P  < .0001]）。INPP5A 评分为 1 与较差的 3 年生存率相关（风险比为 42.3% [风险比，2.81，P  = .0006]），局部转移率为 48.0%（风险比，4.71；P  < .0001 ） ）。

结论

低 INPP5A 评分可预测侵袭性肿瘤，并且可能是指导 cSCC 临床治疗的有用辅助手段。