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The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma
Journal of the American Academy of Dermatology ( IF 12.8 ) Pub Date : 2018-10-22 , DOI: 10.1016/j.jaad.2018.10.018
Helen J L Cumsky 1 , Collin M Costello 2 , Nan Zhang 3 , Richard Butterfield 3 , Matthew R Buras 3 , Jessica E Schmidt 2 , Kevin Drenner 2 , Steven A Nelson 2 , Shari A Ochoa 2 , Christian L Baum 4 , Mark R Pittelkow 2 , David J DiCaudo 2 , Aleksandar Sekulic 2 , Aaron R Mangold 2
Affiliation  

Background

Inositol polyphosphate 5-phosphatase (INPP5A) has been shown to play a role in development and progression of cutaneous squamous cell carcinoma (cSCC). The goal of the current study was to explore the prognostic value of INPP5A expression in cSCC.

Methods

A total of 189 cases of actinic keratosis and SCC in 174 patients were identified; clinical and outcome data were abstracted, histopathology was rereviewed, and immunohistochemical staining and interpretation was performed for INPP5A.

Results

The majority of tumors (89.4%) had an INPP5A score of 2 or 3. No patients had complete loss of INPP5A. Tumors with an INPP5A score of 1 were more likely to be intermediate- to high-risk tumors (Brigham and Women's Hospital stage ≥T2a 85.0% vs 23.7% [P < .0001]) characterized by a larger diameter (2.4 cm vs 1.3 cm [P = .0004]), moderate-to-poor differentiation (86.7% vs 17.6% [P < .0001]), and perineural invasion (37.5% vs 5.3%, [P < .0001]). An INPP5A score of 1 was associated with a worse 3-year survival (a rate of 42.3% [hazard ratio, 2.81, P = .0006]) and a local metastasis rate of 48.0% (hazard ratio, 4.71; P < .0001).

Conclusions

Low INPP5A scores are predictive of aggressive tumors and may be a useful adjunct to guide clinical management of cSCC.



中文翻译:

肌醇多磷酸5-磷酸酶对皮肤鳞状细胞癌的预后价值

背景

肌醇多磷酸 5-磷酸酶 (INPP5A) 已被证明在皮肤鳞状细胞癌 (cSCC) 的发生和进展中发挥作用。本研究的目的是探讨 INPP5A 表达在 cSCC 中的预后价值。

方法

174 名患者中,共鉴定出 189 例光化性角化病和鳞状细胞癌;提取临床和结果数据,重新审查组织病理学,并对 INPP5A 进行免疫组织化学染色和解释。

结果

大多数肿瘤 (89.4%) 的 INPP5A 评分为 2 或 3。没有患者的 INPP5A 完全丧失。INPP5A 评分为 1 的肿瘤更有可能是中高危肿瘤(布莱根妇女医院分期 ≥T2a 85.0% vs 23.7% [ P < .0001]),其特点是直径较大(2.4 cm vs 1.3 cm  ) [ P  = .0004])、中度至低分化(86.7% vs 17.6% [ P  < .0001])和神经周围侵犯(37.5% vs 5.3%,[ P  < .0001])。INPP5A 评分为 1 与较差的 3 年生存率相关(风险比为 42.3% [风险比,2.81,P  = .0006]),局部转移率为 48.0%(风险比,4.71;P  < .0001 ) )。

结论

低 INPP5A 评分可预测侵袭性肿瘤,并且可能是指导 cSCC 临床治疗的有用辅助手段。

更新日期:2018-10-22
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