Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus cheliensis. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of (-)-(4S,5S,6R,7S,8S)-goniochelienlactone and (-)-(4S,5S,6R,7S,8S)-7-acetylgoniochelienlactone were established from single crystal X-ray analysis using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparisons of their ECD spectra with those of related known compounds. Most of the isolated compounds were evaluated for their cytotoxicities against human colorectal cancer cells (HCT-116). Griffithazanone A was the most potent with an IC50 value of 2.39 μM.

中文翻译：

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来自 Goniothalamus cheliensis 的生物碱和苯乙烯内酯

八种以前未描述的化合物，包括四种生物碱和五种苯乙烯内酯以及 36 种已知化合物是从 Goniothalamus cheliensis 的树枝和叶子提取物中分离出来的。通过对其光谱数据的广泛分析，阐明了它们的结构。(-)-(4S,5S,6R,7S,8S)-goniochelienlactone 和 (-)-(4S,5S,6R,7S,8S)-7-acetylgoniochelienlactone 的绝对构型由单晶 X 射线分析确定使用 Cu Kα 辐射。其他相关化合物的绝对构型是通过将它们的 ECD 光谱与相关已知化合物的 ECD 光谱进行比较来确定的。评估了大多数分离的化合物对人结肠直肠癌细胞 (HCT-116) 的细胞毒性。Griffithazanone A 是最有效的，IC50 值为 2.39 μM。