Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each format have implications for engaging the immune system. Elimination of HIV will need sophisticated approaches with immunotherapies being one of the strategies under investigation. Furthermore, HIV genetic variability and functional compromise of the adaptive CTL response complicate the potential usefulness of some immunotherapeutic strategies. Inclusion of novel HIV neutralizing Abs with high potency and breadth as components of bsAbs could represent alternative strategies for virus elimination by harnessing the adaptive immune response in vivo.

中文翻译：

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双特异性抗体：用于 HIV 治疗的潜在免疫疗法

双特异性 (bs) 抗体（Abs、bsAbs）是一种工程化的免疫球蛋白，在一个分子中包含两个不同的抗原结合位点。bsAbs 可以分为两种分子形式；IgG 样和非 IgG 样。每种形式的结构元素对免疫系统的参与都有影响。消除艾滋病毒需要复杂的方法，免疫疗法是正在研究的策略之一。此外，HIV 遗传变异性和适应性 CTL 反应的功能妥协使某些免疫治疗策略的潜在用途复杂化。将具有高效力和广度的新型 HIV 中和抗体作为 bsAb 的组成部分包含在内，可以代表通过利用体内适应性免疫反应消除病毒的替代策略。