Electrochemical Dehydrogenative Cross‐Coupling of Quinoxalin‐2(1H)‐ones with Amines for the Synthesis of 3‐Aminoquinoxalinones,Advanced Synthesis & Catalysis

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Electrochemical Dehydrogenative Cross‐Coupling of Quinoxalin‐2(1H)‐ones with Amines for the Synthesis of 3‐Aminoquinoxalinones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-11-19 , DOI: 10.1002/adsc.201800989
Ke-Jing Li ₁ , Kun Xu ₁ , Yong-Guo Liu ₂ , Cheng-Chu Zeng ₁ , Bao-Guo Sun ₂

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An efficient protocol for the synthesis of 3‐aminoquinoxalinones via the electrochemical dehydrogenative C‐3 amination of quinoxalin‐2(1H)‐ones was developed. With aliphatic amines and azoles as the nitrogen sources, a series of 3‐aminoquinoxalinones was obtained in up to 99% yield. This direct electrolytic method avoids the use of transition metals and external oxidants, and represents an appealing alternative for the synthesis of 3‐aminoquinoxalinones.

中文翻译：

喹喔啉-2（1H）-酮与胺的电化学脱氢交叉偶联，用于合成3-氨基喹喔啉酮

通过喹喔啉-2（1 H）-酮的电化学脱氢C-3胺化反应，开发了一种高效的3-氨基喹喔啉酮合成方法。以脂肪族胺和唑类为氮源，可以以高达99％的收率获得一系列3-氨基喹喔啉酮。这种直接电解方法避免了使用过渡金属和外部氧化剂，是合成3-氨基喹喔啉酮的有吸引力的替代方法。

更新日期：2018-11-19

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