Chemoselective Pd‐Catalyzed C‐TeCF3 Coupling of Aryl Iodides,Angewandte Chemie International Edition

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Chemoselective Pd‐Catalyzed C‐TeCF3 Coupling of Aryl Iodides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-11-20 , DOI: 10.1002/anie.201810950
Theresa Sperger ₁ , Sinem Guven ₁ , Franziska Schoenebeck ₁

Affiliation

While the TeCF₃ moiety features promising properties and potential in a range of applications, no direct synthetic method exists for its incorporation into aromatic scaffolds. This report features the first direct catalytic method for the formation of C(sp²)−TeCF₃ bonds. The method relies on a Pd/Xantphos catalytic system and allows for the trifluoromethyltellurolation of aryl iodides. Our computational and experimental mechanistic analyses shed light on the privileged activity of Xantphos in this transformation.

中文翻译：

芳基碘化物的化学选择性Pd催化C-TeCF3偶联

尽管TeCF ₃部分在一系列应用中具有令人鼓舞的特性和潜力，但尚无直接合成方法将其掺入芳族支架中。该报告的特点是形成C（sp ²）-TeCF ₃键的第一种直接催化方法。该方法依赖于Pd / Xantphos催化体系，并允许芳基碘化物的三氟甲基碲酸化。我们的计算和实验机制分析揭示了Xantphos在此转换中的特权活动。

更新日期：2018-11-20

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