An analytical method for the simultaneous determination of iodide and iodate by reversed phase liquid chromatography with ultraviolet detection using imidazolium ionic liquids as mobile phase additives was developed in this paper. Imidazolium ionic liquids, pyridinium ionic liquids, and common ion pair reagent tetrabutylammonium hydroxide as mobile phase additives were compared. The results indicated that imidazolium ionic liquids as the mobile phase additives were better than any tetrabutylammonium hydroxide or pyridinium ionic liquids. The relevant mechanisms of separation and detection for the anions were discussed. Imidazolium ionic liquids acted as ion pair reagents and ultraviolet absorption reagents in the separation and detection of the anions. The optimized mobile phase of methanol/0.3 mmol/L 1-hexyl-3-methylimidazolium tetrafluoroborate aqueous solutions (12/88, v/v), detection wavelength of 210 nm, and column temperature of 35 °C were used for the determination of iodide and iodate. Under these conditions, the detection limits of iodide and iodate were 0.02 and 0.03 mg/L, respectively. To evaluate the practicability of the method, the determination of iodide and iodate in medicines and beverages was performed by this method. The results are that the spiked recoveries were greater than 95% and RSD was less than 3.0%. The method was simple, accurate, and reliable and could provide a reference for the analysis of iodide and iodate.

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本文建立了一种咪唑鎓离子液体作为流动相添加剂的反相液相色谱-紫外检测同时测定碘化物和碘酸盐的分析方法。比较了咪唑鎓离子液体，吡啶鎓离子液体和常见的离子对试剂氢氧化四丁基铵作为流动相添加剂。结果表明，作为流动相添加剂的咪唑鎓离子液体优于任何氢氧化四丁铵或吡啶鎓离子液体。讨论了分离和检测阴离子的相关机理。咪唑鎓离子液体在阴离子的分离和检测中充当离子对试剂和紫外线吸收剂。优化的甲醇/ 0流动相。（v / v），检测波长为210 nm和柱温为35°C来测定碘化物和碘酸盐。在这些条件下，碘化物和碘酸盐的检出限分别为0.02和0.03 mg / L。为了评估该方法的实用性，通过该方法对药品和饮料中的碘化物和碘酸盐进行了测定。结果是加标回收率大于95％，RSD小于3.0％。该方法简便，准确，可靠，可为碘化物和碘酸盐的分析提供参考。

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