Adolescence is a time of physical, psychological and social changes between childhood and adulthood. All adolescents and young adults (AYAs) are in transition and experience key underlying processes that will influence their later life. It is a critical period, particularly for AYAs with a chronic medical condition. Diseases can start at any point during adolescence. The transition of care will concern health care providers, as well as more unexpected actors such as social workers, teachers, business managers and the family. In this review, we focus on transition in primary immunodeficiencies (PIDs) and autoimmune diseases (AIDs). We describe the challenges and needs of transition in the field. Questions that AYAs with PID and/or AID must face during transition in their familial, professional and personal life are discussed. We expose a practical, AYA centered approach to help physicians in their daily practice, and we propose a position for the future.

青春期是从童年到成年之间身体，心理和社会变化的时期。所有青少年都在过渡中，并经历了会影响他们晚年生活的关键潜在过程。这是关键时期，特别是对于患有慢性疾病的AYA。疾病可以在青春期的任何时候开始。医疗服务的过渡将涉及医疗服务提供者，以及社会工作者，教师，业务经理和家庭等更多意外行为者。在这篇综述中，我们集中于原发性免疫缺陷（PID）和自身免疫性疾病（AID）的过渡。我们描述了该领域的挑战和过渡需求。讨论了具有PID和/或AID的AYA在其家庭，职业和个人生活过渡期间必须面对的问题。我们展示了一个实用的