Background

Melanoma incidence has increased; the primary modifiable risk factor is ultraviolet radiation (UVR) from the sun or artificial UVR (arUVR) from tanning beds.

Objective

To determine whether patients who developed melanoma after arUVR exposure from tanning beds have unique characteristics.

Methods

A retrospective study of 434 melanoma patients was performed. Patients who consented at the initial appointment completed a questionnaire regarding phenotypic traits, medical history, and UVR exposure.

Results

Compared with patients aged ≥40 years, younger patients, especially women, had greater lifetime exposure to arUVR. At any age, patients with multiple primary melanomas had a higher probability of exposure to arUVR. For all patients with additional primary melanomas, those exposed to arUVR acquired their second primary melanoma significantly earlier; 67% of patients exposed to arUVR through tanning beds had their second primary diagnosed at the time of or within 1 year of their original diagnosis compared with 28% of nontanners (P = .011). Median time to diagnosis of second primary melanoma in patients exposed to arUVR versus those not exposed was 225 days versus 3.5 years, respectively (P = .027).

Limitations

The study was conducted in 1 geographic area with a relatively small sample size.

Conclusion

Our findings provide evidence for heightened surveillance in melanoma patients exposed to arUVR.

中文翻译：

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第二原发性黑色素瘤：暴露于晒黑床的患者风险增加，呈现时间减少

背景

黑色素瘤的发病率增加了；主要的可修改风险因素是来自太阳的紫外线（UVR）或来自晒黑床的人造UVR（arUVR）。

客观的

要确定在arUVR暴露于晒黑床上后发展成黑色素瘤的患者是否具有独特的特征。

方法

回顾性研究434例黑色素瘤患者。初次同意的患者填写了有关表型特征，病史和UVR暴露的问卷。

结果

与年龄≥40岁的患者相比，年轻患者，尤其是女性，终生暴露于arUVR的可能性更大。在任何年龄，患有多个原发性黑色素瘤的患者都有较高的暴露于arUVR的可能性。对于所有其他原发性黑色素瘤患者，暴露于arUVR的患者明显较早地获得了第二个原发性黑色素瘤。通过晒黑床暴露于arUVR的患者中，有67％的人在最初诊断时或最初诊断后的一年内被确诊为第二原发性疾病，而非鞣制者为28％（P  = .011）。暴露于arUVR的患者与未暴露的患者相比，诊断第二原发性黑色素瘤的中位时间分别为225天和3.5年（P  = .027）。

局限性

该研究是在1个地理区域内进行的，样本量相对较小。

结论

我们的发现为在暴露于arUVR的黑色素瘤患者中加强监测提供了证据。