Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets†,RSC Advances

当前位置： X-MOL 学术 › RSC Adv. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets†
RSC Advances ( IF 3.9 ) Pub Date : 2018-10-19 00:00:00 , DOI: 10.1039/c8ra07441k
Solomon Tiruneh Dibaba ₁ , Ruoyan Wei ₂ , Wensong Xi ₃ , Lei Zhao ₂ , Liyi Shi ₂ , Wei Ren ₁ , Torsten Mayr ₄ , Lining Sun _{1,

2}

Affiliation

An anti-cancer campaign might not be easily achieved through a single therapeutic modality. Collaboration of multimodal therapies and diagnosis could be vital to win the battle against cancer. In this context, we synthesized a multifunctional theranostic nanocomposite (UCNP–BPNS) from upconversion nanoparticles (UCNP) and black phosphorus nanosheets (BPNS) for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging. Core–shell UCNP (NaYF₄:Yb,Er@NaGdF₄) and BPNS were synthesized using solvo-thermal and liquid exfoliation methods, respectively, and then covalently conjugated after UCNP was modified with polyacrylic acid and BPNS with methoxypolyethylene glycol amine. The experimental results validate that the nanocomposite exhibited a good photothermal therapy (PTT) effect under 808 nm laser irradiation, endorsing the apparent heat conversion effect of BPNS. Besides, a very good photodynamic therapy (PDT) effect was achieved under 980 nm laser irradiation of the nanocomposite due to Förster resonance energy transfer from UCNP to BPNS that generated singlet oxygen (¹O₂). The synergistic PTT/PDT therapeutic effect provided by UCNP–BPNS under simultaneous 808 and 980 nm laser irradiation was significantly higher than either PTT or PDT alone. Furthermore, due to the merit of the outer shell coated on the surface of the core of UCNP, the nanocomposite exhibited good potential for magnetic resonance and upconversion luminescence imaging. These results demonstrated that our multifunctional nanocomposite has promising theranostic efficacy under near infrared laser irradiation.

中文翻译：

由上转换发光纳米粒子和黑磷纳米片制成的治疗诊断纳米复合材料†

通过单一的治疗方式可能不容易实现抗癌运动。多模式治疗和诊断的合作对于赢得与癌症的斗争至关重要。在此背景下，我们从上转换纳米粒子 (UCNP) 和黑磷纳米片 (BPNS) 合成了多功能治疗诊断纳米复合材料 (UCNP-BPNS)，用于体外协同光热/光动力疗法和双模成像。核壳 UCNP (NaYF ₄ :Yb,Er@NaGdF ₄) 和 BPNS 分别采用溶剂热法和液体剥离法合成，然后用聚丙烯酸改性 UCNP 和用甲氧基聚乙二醇胺改性 BPNS 后共价共轭。实验结果验证了纳米复合材料在 808 nm 激光照射下表现出良好的光热治疗 (PTT) 效果，证明了 BPNS 的明显热转换效果。此外，由于从 UCNP 到 BPNS 的 Förster 共振能量转移产生单线态氧 ( ¹ O ₂）。UCNP-BPNS 在同时 808 和 980 nm 激光照射下提供的协同 PTT/PDT 治疗效果显着高于单独的 PTT 或 PDT。此外，由于外壳包裹在 UCNP 核表面的优点，该纳米复合材料在磁共振和上转换发光成像方面表现出良好的潜力。这些结果表明，我们的多功能纳米复合材料在近红外激光照射下具有良好的治疗效果。

更新日期：2018-10-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11