A Pt prodrug polyphenol and gadolinium ion loaded cancer theranostics nanoplatform based on mild acidic pH and thermal sensitive polymer was designed for photoacoustic (PA)/ magnetic resonance(MR)/ positron emission tomography (PET) multimodal imaging-guided chemo-photothermal combination therapy. The Pt drug release can be controlled by tumour-specific acidic pH and heat generated by external NIR irradiation. The nanoparticles were stable under normal physiological environment and released the drug under tumour acidic pH and NIR laser irradiation, which can reduce the side effect of drug to normal organs. Moreover, the MR signal can be significantly enhanced (~3-fold increase in T1 relaxivity) under the acidic tumour microenvironment, which is favorable for cancer diagnosis. The nanoparticles exhibited excellent tumour accumulation and led to complete tumour eradication with low power NIR laser irradiation. This promising approach provides a new avenue for imaging-guided combination therapy.

中文翻译：

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基于肿瘤微环境响应的半导体聚合物自组装纳米治疗学。

基于弱酸性pH和热敏聚合物的铂前药多酚和钆离子负载癌症治疗诊断纳米平台被设计用于光声（PA）/磁共振（MR）/正电子发射断层扫描（PET）多模态成像引导的化学光热联合治疗。Pt 药物的释放可以通过肿瘤特异性的酸性 pH 值和外部近红外辐射产生的热量来控制。纳米粒子在正常生理环境下稳定，在肿瘤酸性pH和近红外激光照射下释放药物，可减少药物对正常器官的副作用。此外，在酸性肿瘤微环境下，MR信号可以显着增强（T1弛豫率增加约3倍），这有利于癌症诊断。纳米颗粒表现出出色的肿瘤积累能力，并通过低功率近红外激光照射完全根除肿瘤。这种有前景的方法为影像引导联合治疗提供了新途径。