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High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics†
RSC Advances ( IF 3.9 ) Pub Date : 2018-10-18 00:00:00 , DOI: 10.1039/c8ra06190d Hong-Lian Zhang 1 , Ai-Hua Zhang 1 , Xiao-Hang Zhou 1 , Hui Sun 1 , Xiang-Qian Wang 1 , Liu Liang 2 , Xi-Jun Wang 1, 2, 3
RSC Advances ( IF 3.9 ) Pub Date : 2018-10-18 00:00:00 , DOI: 10.1039/c8ra06190d Hong-Lian Zhang 1 , Ai-Hua Zhang 1 , Xiao-Hang Zhou 1 , Hui Sun 1 , Xiang-Qian Wang 1 , Liu Liang 2 , Xi-Jun Wang 1, 2, 3
Affiliation
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Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APCmin/+ mice model. Oral administration of mirabilite was started from the ninth month, while the same dosage of distilled water was given to both the control group and the model group. Based on lipidomics, we collected serum samples of all mice at the 20th week and used a non-targeted method to identify the lipid biomarkers of CRC. Compared with C57BL/6J mice, the metabolic profile of CRC model mice was significantly disturbed, and we identified that 25 lipid-related biomarkers, including linoleic acid, 2-hydroxybutyric acid, 6-deoxocastasterone, hypoxanthine, PC(16:1), PC(18:4), and retinyl acetate, were associated with CRC. According to the abovementioned results, there were six lipid molecules with significant differences that can be used as new targets for handling of CRC through six metabolic pathways, namely, linoleic acid metabolism, retinol metabolism, propanoate metabolism, arachidonic acid metabolism, biosynthesis of unsaturated fatty acids and purine metabolism. Compared with the model group, the metabolic profiles of these disorders tend to recover after treatment. These results indicated that the lipid molecules associated with CRC were regulated by mirabilite. In addition, we identified seven key lipid molecules, of which four had statistical significance. After administration of mirabilite, all disordered metabolic pathways showed different degrees of regulation. In conclusion, high-throughput lipidomics approach revealed mirabilite regulating the altered lipid metabolism as anticancer therapeutics.
中文翻译：
高通量脂质组学揭示芒硝作为抗癌疗法调节脂质代谢†
脂质代谢改变是癌症的一个新兴标志。芒硝对结直肠癌（CRC）有治疗作用；然而，其代谢机制仍不清楚。本研究旨在探索芒硝在 APC min/+小鼠模型中保护结直肠癌的潜在治疗靶点。从第9个月开始口服芒硝，同时对照组和模型组给予相同剂量的蒸馏水。基于脂质组学，我们在 20日收集了所有小鼠的血清样本。周并使用非靶向方法鉴定CRC的脂质生物标志物。与 C57BL/6J 小鼠相比，CRC 模型小鼠的代谢特征明显受到干扰，我们确定了 25 种脂质相关的生物标志物，包括亚油酸、2-羟基丁酸、6-脱氧卡斯特酮、次黄嘌呤、PC(16:1)、 PC(18:4) 和醋酸视黄酯与 CRC 相关。根据上述结果，通过亚油酸代谢、视黄醇代谢、丙酸代谢、花生四烯酸代谢、不饱和脂肪生物合成等六种代谢途径，有六种差异显着的脂质分子可作为治疗CRC的新靶点。酸和嘌呤代谢。与模型组相比，这些疾病的代谢特征在治疗后趋于恢复。这些结果表明与CRC相关的脂质分子受芒硝的调节。此外，我们确定了七个关键脂质分子，其中四个具有统计学意义。芒硝给药后，所有紊乱的代谢途径均表现出不同程度的调节。总之，高通量脂质组学方法揭示了芒硝作为抗癌治疗剂调节改变的脂质代谢。
更新日期：2018-10-18
中文翻译：
高通量脂质组学揭示芒硝作为抗癌疗法调节脂质代谢†
脂质代谢改变是癌症的一个新兴标志。芒硝对结直肠癌（CRC）有治疗作用；然而，其代谢机制仍不清楚。本研究旨在探索芒硝在 APC min/+小鼠模型中保护结直肠癌的潜在治疗靶点。从第9个月开始口服芒硝，同时对照组和模型组给予相同剂量的蒸馏水。基于脂质组学，我们在 20日收集了所有小鼠的血清样本。周并使用非靶向方法鉴定CRC的脂质生物标志物。与 C57BL/6J 小鼠相比，CRC 模型小鼠的代谢特征明显受到干扰，我们确定了 25 种脂质相关的生物标志物，包括亚油酸、2-羟基丁酸、6-脱氧卡斯特酮、次黄嘌呤、PC(16:1)、 PC(18:4) 和醋酸视黄酯与 CRC 相关。根据上述结果，通过亚油酸代谢、视黄醇代谢、丙酸代谢、花生四烯酸代谢、不饱和脂肪生物合成等六种代谢途径，有六种差异显着的脂质分子可作为治疗CRC的新靶点。酸和嘌呤代谢。与模型组相比，这些疾病的代谢特征在治疗后趋于恢复。这些结果表明与CRC相关的脂质分子受芒硝的调节。此外，我们确定了七个关键脂质分子，其中四个具有统计学意义。芒硝给药后，所有紊乱的代谢途径均表现出不同程度的调节。总之，高通量脂质组学方法揭示了芒硝作为抗癌治疗剂调节改变的脂质代谢。
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