Scale-Up of a Continuous Extraction Process for Driving an Equilibrium-Limited Reaction to Completion,Organic Process Research & Development

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Scale-Up of a Continuous Extraction Process for Driving an Equilibrium-Limited Reaction to Completion
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-10-16 00:00:00 , DOI: 10.1021/acs.oprd.8b00260
Michael T. Tudesco ₁ , Eric G. Moschetta ₁ , Eric A. Voight ₂

Affiliation

We report a strategy for implementing a scalable continuous extraction to drive an equilibrium-limited reaction to completion. Our approach is simple, requiring only standard equipment and glassware, and can be designed to meet the needs of the process (e.g., reduced cycle time or reduced solvent use) with minimal development time. We investigated the process parameters, such as the flow rate of fresh n-heptane (extracting solvent) into the system, at a 0.5–5 g scale and reduced the overall time and total amount of n-heptane needed to drive the reaction to completion. The improved conditions for the extraction were demonstrated at the 50 g scale, leading to a similar yield of the desired product and total reaction time as at the 5 g scale, verifying that our reactions and extraction conditions were scalable. In particular, our fit-for-purpose approach is customizable to a number of systems and can be implemented in a short period of time with a limited amount of material.

中文翻译：

扩大连续萃取过程的规模，以推动平衡受限的反应完成

我们报告了一种策略，该策略用于实施可扩展的连续提取，以驱动平衡受限的反应完成。我们的方法很简单，只需要标准设备和玻璃器皿，并且可以设计为以最小的开发时间满足工艺需求（例如，减少循环时间或减少溶剂用量）。我们研究了工艺参数，例如新鲜正庚烷（萃取溶剂）进入系统的流速为0.5-5 g，减少了总时间和总n量。-庚烷需要驱动反应完成。在50 g规模上证明了改善的提取条件，从而获得了与5 g规模上相似的所需产物收率和总反应时间，证明了我们的反应和提取条件是可扩展的。特别是，我们的“适合目的”方法可针对许多系统进行定制，并且可以在短时间内使用有限的材料来实现。

更新日期：2018-10-16

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