Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy,Nano Letters

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Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy
Nano Letters ( IF 9.6 ) Pub Date : 2018-10-16 00:00:00 , DOI: 10.1021/acs.nanolett.8b02670
Xiao-Qiang Wang ₁ , Mengyun Peng ₁ , Chu-Xin Li ₁ , Yu Zhang ₁ , Mingkang Zhang ₁ , Ying Tang ₂ , Miao-Deng Liu ₁ , Bo-Ru Xie ₁ , Xian-Zheng Zhang ₁

Affiliation

Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, and further study of their therapeutic mechanism by real-time imaging is of great importance to explore their biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP for hypoxic tumor therapy; the AuNC-V057-TPP not only exhibits good therapeutic effect under both hypoxic and normoxic conditions but also can monitor the release of free radicals in real-time both in vitro and in vivo. What is more, with the mitochondria-targeting ability, the AuNC-V057-TPP is demonstrated with improved antitumor efficacy through enhanced free radical level in mitochondria, which leads to mitochondrial membrane damage and ATP production reduction and finally induces cancer cell apoptosis.

中文翻译：

实时成像的线粒体靶向缺氧肿瘤治疗的自由基。

自由基已成为缺氧肿瘤治疗的新型和有希望的候选者，通过实时成像进一步研究其治疗机制对探索其生物医学应用具有重要意义。在这里，我们提出了一种用于缺氧肿瘤治疗的智能自由基发生器AuNC-V057-TPP。所述AuNC-V057-TPP不仅表现出良好的治疗效果都低氧和含氧量正常条件下，但也可以监视自由基实时两者释放的体外和体内。此外，具有线粒体靶向能力的AuNC-V057-TPP通过增强线粒体中的自由基水平而具有增强的抗肿瘤功效，从而导致线粒体膜损伤和ATP生成减少，并最终诱导癌细胞凋亡。

更新日期：2018-10-16

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