Post-Fermentation Recovery of Biobased Carboxylic Acids,ACS Sustainable Chemistry & Engineering

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Post-Fermentation Recovery of Biobased Carboxylic Acids
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-10-16 00:00:00 , DOI: 10.1021/acssuschemeng.8b03703
Eric M. Karp ₁ , Robin M. Cywar ₁ , Lorenz P. Manker ₁ , Patrick O. Saboe ₁ , Claire T. Nimlos ₁ , Davinia Salvachúa ₁ , Xiaoqing Wang ₁ , Brenna A. Black ₁ , Michelle L. Reed ₁ , William E. Michener ₁ , Nicholas A. Rorrer ₁ , Gregg T. Beckham ₁

Affiliation

Carboxylic acids are common products produced from the bioconversion of renewable feedstocks. In these processes the separation of the acid product from fermentation broth is the most energy and cost intensive unit operation. Thus, the development of robust, scalable separation approaches that can be applied to a variety of carboxylates is of critical importance to the development of processes that utilize carboxylic acids as platform chemicals. Here we report a batch separation method that includes cell and particulate removal, cation exchange, activated carbon treatment, dewatering with a polymer resin, and product recovery. This method is demonstrated on two unique fermentation broths both derived from corn stover hydrolysate to separate neat succinic and propionic acid. For succinic acid, a crystallization yield of 91% with a product purity of 99.93% was achieved. To our knowledge this is the highest reported crystallization yield and purity for the recovery of succinic acid. Additionally, the method requires approximately 50% less energy compared to standard evaporative crystallization approaches. For propionic acid, neat liquid product was obtained with a distillation yield of 80% and purity of 98%. These excellent results achieved in terms of yield and purity for succinic and propionic acid, two acids with widely different physical properties, from chemically complex hydrolysate broth demonstrates the effective and robust nature of this approach.

中文翻译：

生物基羧酸发酵后回收

羧酸是通过可再生原料的生物转化生产的普通产品。在这些过程中，从发酵液中分离酸产物是最耗费能源和成本的单元操作。因此，开发可应用于多种羧酸盐的稳健，可扩展的分离方法对于开发利用羧酸作为平台化学品的工艺至关重要。在这里，我们报告了一种分批分离方法，其中包括去除细胞和微粒，阳离子交换，活性炭处理，用聚合物树脂脱水以及产品回收。在两种独特的发酵液（均来自玉米秸秆水解产物）中分离出纯净的琥珀酸和丙酸时，证明了该方法。对于琥珀酸，获得了91％的结晶产率和99.93％的产物纯度。据我们所知，这是回收琥珀酸的最高结晶产率和纯度。另外，与标准的蒸发结晶方法相比，该方法所需的能量减少了约50％。对于丙酸，获得纯净的液体产物，蒸馏产率为80％，纯度为98％。从复杂的水解产物肉汤中得到的琥珀酸和丙酸（两种物理性质差异很大的酸）的收率和纯度方面，这些优异的结果证明了这种方法的有效性和鲁棒性。与标准的蒸发结晶方法相比，该方法所需的能量减少了约50％。对于丙酸，获得纯净的液体产物，蒸馏产率为80％，纯度为98％。从复杂的水解产物肉汤中得到的琥珀酸和丙酸（两种物理性质差异很大的酸）的收率和纯度方面，这些优异的结果证明了这种方法的有效性和鲁棒性。与标准的蒸发结晶方法相比，该方法所需的能量减少了约50％。对于丙酸，获得纯净的液体产物，蒸馏产率为80％，纯度为98％。从复杂的水解产物肉汤中得到的琥珀酸和丙酸（两种物理性质差异很大的酸）的收率和纯度方面，这些优异的结果证明了这种方法的有效性和鲁棒性。

更新日期：2018-10-16

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