Chronic inflammation plays a crucial role in the development/progression of diabetic kidney disease. The involvement of tumor necrosis factor (TNF)-related biomarkers [TNFα, progranulin (PGRN), TNF receptors (TNFR1 and TNFR2)] and uric acid (UA) in renal function decline was investigated in patients with type 2 diabetes (T2D). Serum TNF-related biomarkers and UA levels were measured in 594 Japanese patients with T2D and an eGFR ≥30 mL/min/1.73 m². Four TNF-related biomarkers and UA were negatively associated with estimated glomerular filtration rate (eGFR). In a logistic multivariate model, each TNF-related biomarker and UA was associated with lower eGFR (eGFR <60mL /min/1.73 m²) after adjustment for relevant covariates (basic model). Furthermore, UA and TNF-related biomarkers other than PGRN added a significant benefit for the risk factors of lower eGFR when measured together with a basic model (UA, ΔAUC, 0.049, p < 0.001; TNFα, ΔAUC, 0.022, p = 0.007; TNFR1, ΔAUC, 0.064, p < 0.001; TNFR2, ΔAUC, 0.052, p < 0.001) in receiver operating characteristic curve analysis. TNFR ligands were associated with lower eGFR, but the associations were not as strong as those with TNFRs or UA in patients with T2D and an eGFR ≥30 mL/min/1.73 m².

中文翻译：

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循环肿瘤坏死因子相关生物标志物与2型糖尿病估计肾小球滤过率之间的关联。

慢性炎症在糖尿病肾病的发生/发展中起着至关重要的作用。在2型糖尿病（T2D）患者中，研究了肿瘤坏死因子（TNF）相关的生物标志物[TNFα，颗粒蛋白（PGRN），TNF受体（TNFR1和TNFR2）]和尿酸（UA）与肾功能下降的关系。在594名日本T2D和eGFR≥30mL / min / 1.73 m ^2的患者中测定了血清TNF相关的生物标志物和UA水平。四种与TNF相关的生物标志物和UA与估计的肾小球滤过率（eGFR）呈负相关。在Logistic多变量模型中，每个与TNF相关的生物标志物和UA均与较低的eGFR相关（eGFR <60mL /min/1.73 m ²），然后对相关协变量（基本模型）进行调整。此外，与基本模型一起测量时，PGRN以外的UA和TNF相关生物标志物对降低eGFR的危险因素具有显着益处（UA，ΔAUC，0.049，p <0.001；TNFα，ΔAUC，0.022，p = 0.007；受体工作特性曲线分析中的TNFR1，ΔAUC，0.064，p <0.001; TNFR2，ΔAUC，0.052，p <0.001）。TNFR配体与较低的eGFR相关，但在T2D和eGFR≥30mL / min / 1.73 m ^2的患者中，与TNFRs或UA的相关性不强。