Eliminating hepatitis C as a public health threat requires an improved understanding of how to increase testing uptake. We piloted point-of-care testing (POCT) for a current HCV infection in an inner-city Emergency Department (ED) and assessed the influence on uptake of offering concomitant screening for HIV. Over four months, all adults attending ED with minor injuries were first invited to complete an anonymous questionnaire then invited to test in alternating cycles offering HCV POCT or HCV+HIV POCT. Viral RNA was detected in finger-prick blood by GeneXpert. 814/859 (94.8%) questionnaires were returned and 324/814 (39.8%) tests were accepted, comprising 211 HCV tests and 113 HCV+HIV tests. Offering concomitant HIV screening reduced uptake after adjusting for age and previous HCV testing (odds ratio 0.51; 95% confidence interval [CI] 0.38-0.68; p < 0.001). HCV prevalence was 1/324 (0.31%; 95% CI 0.05-1.73); no participant tested positive for HIV. 167/297 (56.2%) POCT participants lived in the most deprived neighbourhoods in England. HCV RNA testing using finger-prick blood was technically feasible. Uptake was moderate and the offer of concomitant HIV screening showed a detrimental impact on acceptability in this low prevalence population. The findings should be confirmed in a variety of other community settings.

中文翻译：

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当前的丙型肝炎病毒感染的护理点筛查：对同时提供HIV筛查的摄取的影响。

消除丙型肝炎作为一种公共卫生威胁，需要对如何增加测试摄入量有更好的了解。我们在市区内急诊室（ED）中对当前的HCV感染进行了现场即时检测（POCT），并评估了同时进行HIV筛查对摄入量的影响。在四个月的时间里，首先邀请所有参加ED且受轻伤的成年人填写匿名问卷，然后邀请他们交替进行测试，以提供HCV POCT或HCV + HIV POCT。GeneXpert在手指刺血中检测到病毒RNA。返回了814/859（94.8％）的调查问卷，并接受了324/814（39.8％）的测试，包括211 HCV测试和113 HCV + HIV测试。调整年龄和先前的HCV检测后，提供伴随的HIV筛查可减少摄入量（优势比0.51； 95％置信区间[CI] 0.38-0.68；p <0.001）。HCV患病率为1/324（0.31％; 95％CI 0.05-1.73）; 没有参与者的艾滋病毒检测呈阳性。167/297（56.2％）POCT参与者生活在英格兰最贫困的社区。使用指尖采血进行HCV RNA检测在技术上是可行的。摄入量适中，同时进行艾滋病毒筛查显示对这一低患病率人群的可接受性有不利影响。这些发现应在其他各种社区环境中得到确认。摄入量适中，同时进行艾滋病毒筛查显示对这一低患病率人群的可接受性有不利影响。这些发现应在其他各种社区环境中得到确认。摄入量适中，同时进行艾滋病毒筛查显示对这一低流行人群的可接受性有不利影响。这些发现应在其他各种社区环境中得到确认。