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A combination of the finite element analysis and experimental indentation via the cornea.
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2018-10-16 , DOI: 10.1016/j.jmbbm.2018.10.017
Alireza Karimi 1 , Reza Razaghi 2 , Toshihiro Sera 1 , Susumu Kudo 1
Affiliation  

The purpose of this study was to perform a set of experimental indentation test to certify our proposed eye model enables to have a better deformation assessment for the eye globe under the indentation load compared to other eye models. To do that, twenty-four enucleated human globes were removed from the cadavers. A screw at 5 different loading rates indented to the eye globes and the resulting macroscopic force-displacement as a result of the deformation in the apex of the cornea was measured. The experimental results revealed significantly higher stiffness, elastic modulus, and maximum force for the globe at higher loading rates (50 and 100 mm/min) (n = 4 globes, p < 0.05, post hoc Scheffe method) compared to the lower ones (5, 10, and 20 mm/min). The mean stiffness, elastic modulus as well as the mean maximum force of 1.64 ± 0.38 N/mm, 303.40 ± 111.10 kPa, and 53.88 ± 17.63 N (Mean ± SD) were observed for the eye globes under all loading rates, respectively. Our eye model due to incorporating the anterior (cornea, aqueous body, and iris) and posterior (sclera, retina, and vitreous body) components showed a good agreement with force-displacement diagrams compared to that of the experimental results not only at lower but also at higher loading rates.



中文翻译:

通过角膜进行有限元分析和实验压痕的组合。

这项研究的目的是执行一组实验压痕测试,以证明我们提出的眼图与其他眼模型相比,能够在压痕负荷下对眼球进行更好的变形评估。为此,从尸体上取下了二十四个去核的人类地球仪。测量了在5个不同负荷率下的螺钉压入眼球,并测量了由于角膜根尖变形而导致的宏观力位移。实验结果表明,在较高的加载速率(50和100 mm / min)下,球体的刚度,弹性模量和最大力显着提高(n = 4球体,p <0.05,事后Scheffe方法)与较低的(5、10和20 mm / min)相比。在所有加载速率下,观察到的眼球的平均刚度,弹性模量以及平均最大力分别为1.64±0.38 N / mm,303.40±111.10 kPa和53.88±17.63 N(均值±SD)。与实验结果相比,由于结合了前部(角膜,水体和虹膜)和后部(巩膜,视网膜和玻璃体)的眼睛模型,与力-位移图显示出良好的一致性。在较高的加载速率下也是如此。

更新日期:2018-10-16
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