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Synergistic effects between silicon nanowires and doxorubicin at non-toxic doses lead to high-efficacy destruction of cancer cells†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-10-17 00:00:00 , DOI: 10.1039/c8tb02070a
Binbin Chu 1, 2, 3, 4, 5 , Fei Peng 1, 2, 3, 4, 5 , Houyu Wang 1, 2, 3, 4, 5 , Yuanyuan Su 1, 2, 3, 4, 5 , Yao He 1, 2, 3, 4, 5
Affiliation  

We herein provide a synergistic chemotherapeutic strategy by combining silicon nanowires (SiNWs) and doxorubicin (DOX) at nontoxic doses, suitable for high-efficacy destruction of cancer cells. The presented synergistic method can ruin tumors by destroying the cytoskeleton, arresting the cell cycle in the G2 phase, and damaging the mitochondria to release cytochrome C.

中文翻译:

硅纳米线和阿霉素之间在无毒剂量下的协同作用导致癌细胞的高效破坏

我们在本文中通过以无毒剂量组合硅纳米线(SiNWs)和阿霉素(DOX)提供了一种协同化学治疗策略,适用于癌细胞的高效破坏。所提出的协同方法可通过破坏细胞骨架,将细胞周期阻滞在G2期并破坏线粒体以释放细胞色素C来破坏肿瘤。
更新日期:2018-10-17
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