Synergistic effects between silicon nanowires and doxorubicin at non-toxic doses lead to high-efficacy destruction of cancer cells†,Journal of Materials Chemistry B

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Synergistic effects between silicon nanowires and doxorubicin at non-toxic doses lead to high-efficacy destruction of cancer cells†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-10-17 00:00:00 , DOI: 10.1039/c8tb02070a
Binbin Chu _{1,

2,

3,

4,

5} , Fei Peng _{1,

2,

3,

4,

5} , Houyu Wang _{1,

2,

3,

4,

5} , Yuanyuan Su _{1,

2,

3,

4,

5} , Yao He _{1,

2,

3,

4,

5}

Affiliation

We herein provide a synergistic chemotherapeutic strategy by combining silicon nanowires (SiNWs) and doxorubicin (DOX) at nontoxic doses, suitable for high-efficacy destruction of cancer cells. The presented synergistic method can ruin tumors by destroying the cytoskeleton, arresting the cell cycle in the G2 phase, and damaging the mitochondria to release cytochrome C.

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