Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes,Organic & Biomolecular Chemistry

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Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-17 , DOI: 10.1039/c8ob02205d
Qian Wen Tan _{1,

2,

3,

4,

5} , Praful Chovatia _{5,

6,

7} , Michael C. Willis _{1,

2,

3,

4,

5}

Affiliation

A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of both starting materials, and delivers the desired pyrrolinones in good yields, with high levels of stereocontrol.

中文翻译：

铜催化α-酮酰胺和炔烃的合成亚烷基2-吡咯烷酮衍生物

已经开发了用于合成（E）-亚烷基吡咯烷酮衍生物的Cu（I）催化的加成和环化序列。该反应掺入简单的α-酮酰胺和炔烃作为底物，并使用可商购的Cu（I）催化剂。该方法耐受两种原料的良好变化，并以高收率提供所需的吡咯烷酮，并具有高水平的立体控制。

更新日期：2018-11-02

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