Redox-dependent conformational changes of a proximal [4Fe–4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2†,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Redox-dependent conformational changes of a proximal [4Fe–4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-17 00:00:00 , DOI: 10.1039/c8cc06261g
Noor Dina Muhd Noor _{1,

2,

3,

4,

5} , Hiroaki Matsuura _{1,

2,

3,

4,

5} , Koji Nishikawa _{1,

2,

3,

4,

5} , Hulin Tai _{5,

6,

7,

8,

9} , Shun Hirota _{5,

6,

7,

8,

9} , Jaehyun Kim _{1,

2,

3,

4,

5} , Jiyoung Kang _{1,

2,

3,

4,

5} , Masaru Tateno _{1,

2,

3,

4,

5} , Ki-Seok Yoon _{5,

10,

11,

12,

13} , Seiji Ogo _{5,

10,

11,

12,

13} , Shintaro Kubota _{1,

2,

3,

4,

5} , Yasuhito Shomura _{5,

6,

7,

8,

14} , Yoshiki Higuchi _{1,

2,

3,

4,

5}

Affiliation

Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe–4S] cluster proximal to the Ni–Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe–4S] to display redox-dependent conformational changes. These structural features are proposed to be the key aspects that protect the active site from O₂ attack.

中文翻译：

Hyb型[NiFe]氢化酶中近端[4Fe–4S]簇的氧化还原依赖性构象变化，以保护活性位点免受O ₂†

枸橼酸杆菌属。S-77 [NiFe]-加氢酶在Ni-Fe活性位点附近有一个标准的[4Fe-4S]簇。可重定位的水分子和灵活的天冬氨酸的存在使[4Fe-4S]能够显示出依赖于氧化还原的构象变化。这些结构特征被认为是保护活动站点免受O ₂攻击的关键方面。

更新日期：2018-10-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11