Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH†,Chemical Communications

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Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-16 00:00:00 , DOI: 10.1039/c8cc05405c
Daniel Bermejo-Velasco _{1,

2,

3,

4,

5} , Ganesh N. Nawale _{1,

2,

3,

4,

5} , Oommen P. Oommen _{6,

7,

8,

9,

10} , Jöns Hilborn _{1,

2,

3,

4,

5} , Oommen P. Varghese _{1,

2,

3,

4,

5}

Affiliation

We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner.

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