Micro–Nano‐Texturing Inner Surfaces of Small‐Caliber High Aspect Ratio and Superhydrophobic Artificial Vessels using Femtosecond Laser Filamenting Pulses,Advanced Materials Interfaces

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Micro–Nano‐Texturing Inner Surfaces of Small‐Caliber High Aspect Ratio and Superhydrophobic Artificial Vessels using Femtosecond Laser Filamenting Pulses
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2018-10-16 , DOI: 10.1002/admi.201801148
Xue‐Peng Zhan ₁ , Yi‐Jun Wang ₂ , Yue Su ₁ , Mu‐Tian Li ₁ , Hong‐Wei Zang ₁ , Hong Xia ₁ , Huai‐Liang Xu ₁ , Bin Liu ₂ , Hong‐Bo Sun ₁

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Cardiovascular diseases, the leading cause of death worldwide in the last two decades, are mainly due to the pathological changes inside the heart or blood vessels. Current treatment prescription is to replace obstructed blood vessels by synthetic alternatives, but it can only cure patients effectually when the vessel diameter is larger than a certain value because the cell attachment capacity on a small‐caliber artificial vessel is usually unacceptable for long‐term patency. Here a femtosecond filamenting laser‐based fabrication approach that can produce in situ microstructures on the inner surface of small‐caliber tubules is reported. It is shown that the inner‐surface fabrication with an aspect ratio as high as 10:1 can be achieved and the processed samples exhibit significant changes in physical properties including topography, roughness, hydrophobicity, as well as in biological property with improved ability for Hela cells to adhere and grow. The results provide a possibility toward fabricating small‐caliber artificial vessels that might be suitable for long‐term patency use.

中文翻译：

飞秒激光细丝脉冲的小口径高纵横比和超疏水人造船的微纳米纹理内表面

心血管疾病是近二十年来全球主要的死亡原因，主要是由于心脏或血管内部的病理变化所致。当前的治疗处方是用合成替代物代替阻塞性血管，但是它只能在血管直径大于一定值时有效地治愈患者，因为小口径人造血管上的细胞附着能力通常对于长期通畅而言是不可接受的。本文报道了一种基于飞秒细丝激光的制造方法，该方法可在小口径小管的内表面上产生原位微结构。结果表明，可以实现长宽比高达10：1的内表面加工，并且经过处理的样品在物理特性（包括形貌，粗糙度，疏水性，以及生物学特性，提高了Hela细胞粘附和生长的能力。结果为制造适合长期开放使用的小口径人造血管提供了可能性。

更新日期：2018-10-16

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