当前位置: X-MOL 学术Chem. Eur. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent Progress in Fluorescence Signal Design for DNA‐Based Logic Circuits
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-01-31 , DOI: 10.1002/chem.201804420
Shu Yang 1 , Chunrong Yang 2 , Dan Huang 2 , Lingbo Song 1 , Jianchi Chen 2 , Qianfan Yang 2
Affiliation  

DNA‐based logic circuits, encoding algorithms in DNA and processing information, are pushing the frontiers of molecular computers forward, owing to DNA′s advantages of stability, accessibility, manipulability, and especially inherent biological significance and potential medical application. In recent years, numerous logic functions, from arithmetic to nonarithmetic, have been realized based on DNA. However, DNA can barely provide a detectable signal by itself, so that the DNA‐based circuits depend on extrinsic signal actuators. The signal strategy of carrying out a response is becoming one of the design focuses in DNA‐based logic circuit construction. Although work on sequence and structure design for DNA‐based circuits has been well reviewed, the strategy on signal production lacks comprehensive summary. In this review, we focused on the latest designs of fluorescent output for DNA‐based logic circuits. Several basic strategies are summarized and a few designs for developing multi‐output systems are provided. Finally, some current difficulties and possible opportunities were also discussed.

中文翻译:

基于DNA的逻辑电路的荧光信号设计的最新进展

由于DNA的稳定性,可访问性,可操作性,尤其是固有的生物学意义和潜在的医学应用优势,基于DNA的逻辑电路,DNA编码算法和处理信息正在推动分子计算机的前沿发展。近年来,基于DNA实现了从算术到非算术的众多逻​​辑功能。但是,DNA本身几乎无法提供可检测的信号,因此基于DNA的电路依赖于外部信号致动器。进行响应的信号策略正成为基于DNA的逻辑电路构建中的设计重点之一。尽管对基于DNA的电路的序列和结构设计的工作进行了很好的审查,但信号产生的策略仍缺乏全面的总结。在这篇评论中,我们专注于基于DNA的逻辑电路的荧光输出的最新设计。总结了几种基本策略,并提供了一些用于开发多输出系统的设计。最后,还讨论了当前的一些困难和可能的机会。
更新日期:2019-01-31
down
wechat
bug