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Synthesis of Diverse α‐Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-12-13 , DOI: 10.1002/chem.201804440
Thomas J. Cogswell 1 , Anders Dahlén 1 , Laurent Knerr 1
Affiliation  

Introduction of difluorinated functionality has emerged as a powerful means for conformational design with minimal steric footprint. Synthetic approaches for the preparation of aryl difluoromethylene ether containing novel building blocks were established, enabling the inclusion of the aryl difluoromethylene ether system into macrocyclic scaffolds for the first time.

中文翻译:

多种α-氟烷氧基芳基衍生物的合成及其在氟化大环化合物生成中的应用

二氟官能团的引入已成为构象设计的一种强有力的手段,具有最小的空间足迹。建立了用于制备包含新型结构单元的芳基二氟亚甲基醚的合成方法,使芳基二氟亚甲基醚系统首次纳入大环骨架。
更新日期:2018-12-13
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