Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes,Advanced Materials

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Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes
Advanced Materials ( IF 27.4 ) Pub Date : 2018-10-17 , DOI: 10.1002/adma.201803355
Jeremy R. Sanborn _{1,

2} , Xi Chen _{1,

3} , Yun-Chiao Yao _{1,

3} , Joshua A. Hammons ₁ , Ramya H. Tunuguntla ₁ , Yuliang Zhang ₁ , Christina C. Newcomb ₄ , Jennifer A. Soltis ₄ , James J. De Yoreo _{4,

5} , Anthony Van Buuren ₁ , Atul N. Parikh ₂ , Aleksandr Noy _{1,

3}

Affiliation

Biological membranes provide a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. Here, a fully synthetic biomimetic membrane is reported that incorporates ultra‐efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block‐copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.

中文翻译：

两性嵌段共聚物中的碳纳米管孔作为生物膜的完全合成模拟物。

生物膜是多功能，可调节，精确和高效的分离系统的一个引人入胜的例子。模仿细胞膜结构的仿生膜具有显着提高特异性和通透性的潜力。此处报道了一种完全合成的仿生膜，该膜在嵌段共聚物基质中结合了超高效的1.5纳米直径碳纳米管孔蛋白（CNTP）通道。证明了CNTP在这些膜中维持高的质子和水渗透性。CNTP还可以通过在囊泡区室之间形成允许小分子转运的桥来模拟生物间隙连接的行为。

更新日期：2018-10-17

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