Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-10-17 , DOI: 10.1002/anie.201811546
Martin Dauner ₁ , Andreas Eichinger ₁ , Genia Lücking ₂ , Siegfried Scherer ₂ , Arne Skerra ₁

Affiliation

Bacillus anthracis is the etiologic agent of anthrax disease. In their Communication (DOI: 10.1002/anie.201807442), A. Skerra and co‐workers report on the construction of a variant human lipocalin by protein design that binds the iron(III)⋅petrobactin complex with high affinity. Scavenging of this specific siderophore abolishes supply with the essential metal ion and thus effectively suppresses bacterial growth. The background depicts colonies of an anthrax vaccination strain on blood agar (with kind permission from Costin Stoica, Regnum Prokaryotae; http://www.tgw1916.net).

中文翻译：

重编程人Siderocalin以中和Petrobactin，炭疽芽孢杆菌必不可少的铁清除剂

炭疽杆菌是炭疽病的病原体。A.Skerra及其同事在其交流中（DOI：10.1002 / anie.201807442）报告了通过蛋白质设计构建的人脂环素变异体的构建方法，该蛋白以高亲和力结合铁（III）·petrobactin复合物。该特定铁载体的清除消除了必需金属离子的供应，因此有效地抑制了细菌的生长。背景描绘了血琼脂上的炭疽疫苗接种菌株的菌落（在Costin Stoica，Regnum Prokaryotae的允许下； http：//www.tgw1916.net允许）。

更新日期：2018-10-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11