A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes.,Mucosal Immunology

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A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2019-Jan-01 , DOI: 10.1038/s41385-018-0095-3
Bibiana E Barrios ₁ , Lisa Maccio-Maretto ₁ , F Nicolás Nazar ₂ , Silvia G Correa ₁

Affiliation

Biological rhythms are periodic oscillations that occur in the physiology of the organism and the cells. The rhythms of the immune system are strictly regulated and the circadian alteration seems to have serious consequences. Even so, it is not clear how the immune cells of the intestinal mucosa synchronize with the external environment. Besides, little is known about the way in which biological rhythms affect the critical functions of intestinal immunity, such as oral tolerance. We studied fluctuations in the relevant parameters of intestinal immunity at four different times throughout the day. By using multivariate statistical tools, we found that these oscillations represent at least three different time frames with different conditions for tolerance induction that are altered in Per2ko mice lacking one of the clock genes. Our results allowed us to characterize a window in the final stage of the dark phase that promotes the induction of specific regulatory populations and favors its location in the lamina propria. We show here that, at the end of the intake, the entry of luminal antigens, soluble factors, and leukocyte populations converge in the mesenteric lymph nodes (MLN) and display the greatest potential of the tolerogenic machinery.

中文翻译：

进食期后的选择性窗口有利于肠系膜淋巴结的耐受性诱导。

生物节律是在生物体和细胞的生理机能中发生的周期性振荡。免疫系统的节律受到严格调节，昼夜节律的改变似乎会产生严重的后果。即便如此，目前还不清楚肠粘膜的免疫细胞是如何与外界环境同步的。此外，对于生物节律如何影响肠道免疫的关键功能，如口服耐受性，知之甚少。我们研究了一天中四个不同时间肠道免疫相关参数的波动。通过使用多变量统计工具，我们发现这些振荡代表至少三个不同的时间范围，具有不同的耐受诱导条件，这些时间框架在缺乏时钟基因之一的 Per2ko 小鼠中发生了改变。我们的结果使我们能够在黑暗阶段的最后阶段描述一个窗口，该窗口促进特定调节群体的诱导并有利于其在固有层中的位置。我们在此表明，在摄入结束时，管腔抗原、可溶性因子和白细胞群会聚在肠系膜淋巴结 (MLN) 中，并显示出致耐受性机制的最大潜力。

更新日期：2019-01-26

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