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Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities†
RSC Advances ( IF 3.9 ) Pub Date : 2018-10-15 00:00:00 , DOI: 10.1039/c8ra07549b Lanlan Ge 1, 2, 3 , Haoqiang Wan 1, 4 , Shuming Tang 5 , Haixia Chen 5 , Jiemei Li 1, 4 , Keda Zhang 1 , Boping Zhou 1 , Jia Fei 3 , Shiping Wu 2 , Xiaobin Zeng 1, 4
RSC Advances ( IF 3.9 ) Pub Date : 2018-10-15 00:00:00 , DOI: 10.1039/c8ra07549b Lanlan Ge 1, 2, 3 , Haoqiang Wan 1, 4 , Shuming Tang 5 , Haixia Chen 5 , Jiemei Li 1, 4 , Keda Zhang 1 , Boping Zhou 1 , Jia Fei 3 , Shiping Wu 2 , Xiaobin Zeng 1, 4
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Lonicera japonica Thunb., possesses antiviral and hepatoprotective activities, and is widely used as a health food and in cosmetics. However, its major constituents, caffeoylquinic acid derivatives, and their anti-HBV activity were lacking systematic research. In this study, four novel caffeoylquinic acids, five simple caffeic acids and fourteen known caffeoylquinic acids are isolated and identified from L. japonica. Most caffeoylquinic acids inhibited HBsAg and HBeAg secretion, and HBV DNA replication. In particular, 100 μg ml−1 monocaffeoylquinic acid 9 inhibits HBsAg and HBeAg secretion, and HBV DNA replication by 83.82, 70.76 and 39.36% compared to the control. Unfortunately, 50 μg ml−1 tricaffeoylquinic acid 23 promotes HBsAg and HBeAg secretion, and HBV DNA replication by 172.39, 9.92 and 55.40%. Finally, structure–activity relationships reveal that caffeoylquinic acids containing a caffeoyl group have better inhibitory activities. The results indicate that caffeoylquinic acids from L. japonica could serve as anti-HBV agents for functional food or medicinal use.
中文翻译：
来自 Lonicera japonica Thunb 的新型咖啡酰奎宁酸衍生物。花蕾具有显着的抗乙肝病毒活性†
Lonicera japonica Thunb.具有抗病毒和保肝活性，广泛用作保健食品和化妆品。然而，其主要成分、咖啡酰奎尼酸衍生物及其抗HBV活性缺乏系统研究。在这项研究中，从L. japonica中分离和鉴定了四种新的咖啡酰奎尼酸、五种简单的咖啡酸和十四种已知的咖啡酰奎尼酸。大多数咖啡酰奎宁酸抑制 HBsAg 和 HBeAg 分泌，以及 HBV DNA 复制。特别是，与对照相比，100 μg ml -1 monocaffeoylquinic acid 9抑制 HBsAg 和 HBeAg 分泌，以及 HBV DNA 复制抑制 83.82%、70.76% 和 39.36%。不幸的是，50 μg ml -1三咖啡酰奎尼酸23促进 HBsAg 和 HBeAg 分泌，以及 172.39%、9.92% 和 55.40% 的 HBV DNA 复制。最后，构效关系表明含有咖啡酰基的咖啡酰奎尼酸具有更好的抑制活性。结果表明，来自L. japonica的咖啡酰奎宁酸可作为抗 HBV 药物用于功能性食品或药用。
更新日期：2018-10-15
中文翻译：
来自 Lonicera japonica Thunb 的新型咖啡酰奎宁酸衍生物。花蕾具有显着的抗乙肝病毒活性†
Lonicera japonica Thunb.具有抗病毒和保肝活性，广泛用作保健食品和化妆品。然而，其主要成分、咖啡酰奎尼酸衍生物及其抗HBV活性缺乏系统研究。在这项研究中，从L. japonica中分离和鉴定了四种新的咖啡酰奎尼酸、五种简单的咖啡酸和十四种已知的咖啡酰奎尼酸。大多数咖啡酰奎宁酸抑制 HBsAg 和 HBeAg 分泌，以及 HBV DNA 复制。特别是，与对照相比，100 μg ml -1 monocaffeoylquinic acid 9抑制 HBsAg 和 HBeAg 分泌，以及 HBV DNA 复制抑制 83.82%、70.76% 和 39.36%。不幸的是，50 μg ml -1三咖啡酰奎尼酸23促进 HBsAg 和 HBeAg 分泌，以及 172.39%、9.92% 和 55.40% 的 HBV DNA 复制。最后，构效关系表明含有咖啡酰基的咖啡酰奎尼酸具有更好的抑制活性。结果表明，来自L. japonica的咖啡酰奎宁酸可作为抗 HBV 药物用于功能性食品或药用。
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