An interspecies barrier to tetraploid complementation and chimera formation.,Scientific Reports

当前位置： X-MOL 学术 › Sci. Rep. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An interspecies barrier to tetraploid complementation and chimera formation.
Scientific Reports ( IF 3.8 ) Pub Date : 2018-Oct-16 , DOI: 10.1038/s41598-018-33690-7
Tomoyuki Yamaguchi ₁ , Hideyuki Sato ₁ , Toshihiro Kobayashi _{1,

2} , Megumi Kato-Itoh ₁ , Teppei Goto ₂ , Hiromasa Hara ₂ , Naoaki Mizuno ₁ , Ayaka Yanagida _{1,

3} , Ayumi Umino ₁ , Sanae Hamanaka ₁ , Fabian Suchy ₄ , Hideki Masaki ₁ , Yasunori Ota ₅ , Masumi Hirabayashi ₂ , Hiromitsu Nakauchi _{1,

4}

Affiliation

To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high donor chimerism was associated with anomalies or embryonic death. Organ to organ variation in donor chimerism was greater in interspecies chimeras than in intraspecies chimeras, suggesting species-specific affinity differences among interacting molecules necessary for organogenesis. In interspecies tetraploid complementation, embryo development was near normal until the stage of placental formation, after which no embryos survived.

中文翻译：

四倍体互补和嵌合体形成的种间障碍。

为了研究异种环境中孕体的发育，我们评估了种间嵌合体的形成以及小鼠和大鼠之间的四倍体互补。种间嵌合体中供体 PSC 衍生细胞的总体贡献低于种内嵌合体，并且高供体嵌合性与异常或胚胎死亡相关。种间嵌合体中供体嵌合体的器官间变异大于种内嵌合体，这表明器官发生所需的相互作用分子之间存在物种特异性亲和力差异。在种间四倍体互补中，胚胎发育在胎盘形成阶段之前接近正常，此后没有胚胎存活。

更新日期：2018-10-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11