Injectable Maltodextrin-Based Micelle/Hydrogel Composites for Simvastatin-Controlled Release,Biomacromolecules

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Injectable Maltodextrin-Based Micelle/Hydrogel Composites for Simvastatin-Controlled Release
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-10-15 00:00:00 , DOI: 10.1021/acs.biomac.8b01234
Shifeng Yan ₁ , Jie Ren ₁ , Yuhang Jian ₁ , Weidong Wang ₁ , Wentao Yun ₁ , Jingbo Yin ₁

Affiliation

Injectable hydrogels have shown great potential in bone tissue engineering. Simvastatin (SIM), a common hypolipidemic drug, has been suggested as a potential agent to promote bone regeneration. However, due to its hydrophobic nature, the compatibility between SIM and hydrogels is rather poor, thereby greatly affecting the drug release behavior, the mechanical properties, and dimensional stability of the hydrogels. Herein, we presented a novel design to entrap SIM in an injectable maltodextrin-based micelle/hydrogel composite system. Maltodextrin-based micelles were prepared to solubilize and encapsulate SIM. The SIM-loaded aldehyde-modified micelles were anchored to the hydrogel network and served as a cross-linker to realize improved mechanical strength of hydrogel, controlled release, and osteogenic capability of SIM. In all, this study demonstrated a strategy to incorporate drug loaded carriers into hydrogels for drug delivery and tissue engineering applications.

中文翻译：

辛伐他汀控释的可注射麦芽糊精基胶束/水凝胶复合物

可注射的水凝胶在骨组织工程中显示出巨大的潜力。辛伐他汀（SIM）是一种常见的降血脂药，已被认为是促进骨再生的潜在药物。然而，由于其疏水性，SIM与水凝胶之间的相容性相当差，从而极大地影响了水凝胶的药物释放行为，机械性能和尺寸稳定性。在本文中，我们提出了一种新颖的设计，可将SIM卡入基于麦芽糊精的可注射胶束/水凝胶复合系统中。制备基于麦芽糊精的胶束以溶解和包封SIM。载有SIM的醛修饰胶束固定在水凝胶网络中，并用作交联剂，以提高水凝胶的机械强度，控制释放和SIM的成骨能力。在所有，

更新日期：2018-10-15

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