Introduction: At present, cribriform arrangements are regarded as a pattern of acinar adenocarcinoma. However, recent studies have indicated that clinical outcomes for lung adenocarcinoma patients with cribriform subtype are unfavorable. To validate the prognostic significance of the cribriform pattern, we analyzed a series of 735 Japanese patients with resected lung adenocarcinoma, which was restaged according to the eighth edition of the TNM staging system. Methods: Tumors were classified in accordance with the 2015 WHO classification of lung carcinomas. The cribriform pattern was defined by invasive back‐to‐back fused tumor glands with poorly formed glandular spaces or invasive tumor nests of tumors cells that produce glandular lumina. Recurrence‐free probability (RFP) and overall survival (OS) was analyzed using the log‐rank test and the Cox proportional hazards model. Results: After the addition of the cribriform pattern, 54 of 90 acinar‐predominant tumors were reclassified as cribriform subtype. Five‐year RFP for patients with the cribriform subtype (51%) was lower than it was for patients with acinar and papillary subtype (81% and 80%, respectively) but was comparable to that for patients with solid subtype (48%). Five‐year OS for patients with the cribriform subtype (49%) was lower than it was for patients with acinar and papillary subtype (90% and 81%, respectively). On multivariate analysis adjusted for the eighth edition of the TNM staging system, the cribriform subtype was an independent prognostic factor of a worse RFP and OS. Conclusions: We have validated that the cribriform subtype is an independent factor of poor prognosis in patients with resected lung adenocarcinoma.

中文翻译：

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筛状亚型是肺腺癌患者根据第八版 TNM 分期系统调整后复发和生存的独立预测因子

简介：目前，筛状排列被认为是腺泡腺癌的一种模式。然而，最近的研究表明筛状亚型肺腺癌患者的临床结果是不利的。为了验证筛状模式的预后意义，我们分析了一系列 735 名日本肺腺癌切除患者，这些患者根据 TNM 分期系统的第八版重新分期。方法：按照2015年WHO肺癌分类标准对肿瘤进行分类。筛状模式的定义是具有形成不良腺体空间的侵袭性背对背融合的肿瘤腺体或产生腺腔的肿瘤细胞的侵袭性肿瘤巢。使用对数秩检验和 Cox 比例风险模型分析无复发概率 (RFP) 和总生存期 (OS)。结果：添加筛状模式后，90 例腺泡型肿瘤中有 54 例被重新分类为筛状亚型。筛状亚型患者的五年 RFP (51%) 低于腺泡和乳头状亚型患者 (分别为 81% 和 80%)，但与实体亚型患者 (48%) 相当。筛状亚型患者的五年 OS (49%) 低于腺泡和乳头状亚型患者 (分别为 90% 和 81%)。根据第 8 版 TNM 分期系统调整的多变量分析，筛状亚型是 RFP 和 OS 较差的独立预后因素。结论：