A general approach for a collective synthesis of natural products containing substituted THF ring is described. In this paper, Arbusculone, a small molecule natural product accomplished using a short route, is used as the key intermediate to achieve the total synthesis of Andirolactone, Pinnatolide, Ipomolactone, Cyclocapitelline, Isocyclocapitelline and their two isomers in less than ten steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these natural products from commercially available cheap starting materials.

中文翻译：

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一种无保护基的芳烃酮，雄内酯，频哪内酯，异丙内酯，环己内酯和异环己内酯的合成

描述了用于集体合成含有取代的THF环的天然产物的一般方法。在本文中，使用短路径完成的小分子天然产物Arbusculone被用作关键中间体，可在不到十个步骤的情况下完成Andirolactone，Pinnatolide，Ipomolactone，Cyclocapitelline，Isocyclocapitelline及其两个异构体的全合成。目前的工作着重强调了无保护基团的全部合成方法，以及从市售廉价原料中获得这些天然产物的最短途径。